SIGLEC7 Protein (Leu117Ala-Mutant, Leu118Ala-Mutant) (Fc Tag)
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- 抗原 See all SIGLEC7 蛋白
- SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
- 蛋白类型
- Recombinant
- 产品特性
- Leu117Ala-Mutant, Leu118Ala-Mutant
- 宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This SIGLEC7 protein is labelled with Fc Tag.
- 原理
- Human Siglec-7 / CD328 Protein, Fc (L117A, L118A) Tag (MALS verified)
- 序列
- Gln 19 - Leu 353
- 产品特性
- Human Siglec-7, Fc (L117A, L118A) Tag is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Leu 353 (Accession # Q9Y286-1).
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 0.01 EU per μg by the LAL method.
- 质量等级
- MALS verified
- Top Product
- Discover our top product SIGLEC7 蛋白
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Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) (AA 377-466) protein (GST tag)
SIGLEC7 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) (AA 1-467) protein (GST tag)SIGLEC7 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) (AA 19-353) (Active) protein (His tag)SIGLEC7 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- 应用备注
- This protein carries a Fc (L117A, L118A) tag at the C-terminus. The protein has a calculated MW of 63.3 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Mutations (L117A, L118A/EU number: L234A/L235A) in human immunoglobulin G1 (hIgG1) Fc diminish binding to FcγRI leading to a significant reduction in ADCC and CDC in comparison to wild type human IgG1.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- 25 mM MES, 150 mM NaCl, pH 5.5
- 储存条件
- -20 °C
- 储存方法
- -20°C
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- 抗原
- SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
- 别名
- Siglec-7 / CD328 (SIGLEC7 产品)
- 别名
- SIGLEC7 Protein, AIRM1 Protein, CD328 Protein, CDw328 Protein, D-siglec Protein, QA79 Protein, SIGLEC-7 Protein, SIGLEC19P Protein, SIGLECP2 Protein, p75 Protein, p75/AIRM1 Protein, sialic acid-binding Ig-like lectin 7 Protein, sialic acid binding Ig like lectin 7 Protein, LOC468976 Protein, SIGLEC7 Protein
- 背景
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Synonyms: CDw328,D-siglec,A79 membrane protein,p75,Adhesion inhibitory receptor molecule 1, AIRM-1,
Siglec-7 is a member of the human CD33-related Siglec receptor. The extracellular region of Siglec-7 is characterized by an N-terminal V-set Ig domain that can bind sialic acid and two C2-set Ig domains. The cytoplasmic tail of Siglec-7 has one immune-receptor tyrosine-based inhibitory motif (ITIM) and one ITIM-like motif. Siglec-7 is considered as a sialic acid-dependent immunoreceptor with inhibitory potential and expressed predominantly on human NK cells, monocytes and a small subset of CD8+ T cells. - 分子量
- 63.3 kDa
- NCBI登录号
- NP_055200
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