Sortilin 1 Protein (SORT1) (His-Avi Tag,Biotin)
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- 抗原 See all Sortilin 1 (SORT1) 蛋白
- Sortilin 1 (SORT1)
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Sortilin 1 protein is labelled with His-Avi Tag,Biotin.
- 原理
- Biotinylated Human Sortilin / SORT1 Protein, His,Avitag™ (MALS verified)
- 序列
- Ser 78 - Asn 755
- 产品特性
- Biotinylated Human Sortilin / SORT1, His,Avitag (SON-H82E9) is expressed from human 293 cells (HEK293). It contains AA Ser 78 - Asn 755 (Accession # Q99523-1).
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- 质量等级
- MALS verified
- Top Product
- Discover our top product SORT1 蛋白
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Sortilin 1 (SORT1) (AA 610-754) protein (His tag)
SORT1 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Sortilin 1 (SORT1) (AA 532-831) protein (His-IF2DI Tag)SORT1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
Sortilin 1 (SORT1) (AA 203-299) protein (GST tag)SORT1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Sortilin 1 (SORT1) (AA 78-755) protein (His tag)Crystallography grade SORT1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Sortilin 1 (SORT1) (AA 74-754) protein (His tag)Crystallography grade SORT1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Sortilin 1 (SORT1) (AA 78-831) protein (rho-1D4 tag)Crystallography grade SORT1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Sortilin 1 (SORT1) (AA 74-825) protein (rho-1D4 tag)Crystallography grade SORT1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Sortilin 1 (SORT1) (AA 610-754) protein (His tag)SORT1 宿主: 大鼠 宿主: 酵母菌 Recombinant > 90 % ELISA
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- 应用备注
- This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 79.3 kDa. The protein migrates as 90-100 kDa under reducing (R) condition due to glycosylation.
- 说明
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Ready-to-use Avitag™ biotinylated protein:
The product is exclusively produced using the Avitag™ technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.
This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled. - 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 储存条件
- -20 °C
- 储存方法
- -20°C
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- 抗原
- Sortilin 1 (SORT1)
- 别名
- Sortilin / SORT1 (SORT1 产品)
- 别名
- SORT1 Protein, 19.m02079 Protein, gp95 Protein, ldlcq6 Protein, sortilin Protein, Gp95 Protein, LDLCQ6 Protein, NT3 Protein, 2900053A11Rik Protein, AI852375 Protein, Ntr3 Protein, Ntsr3 Protein, Nt3 Protein, Nts3 Protein, sort1 Protein, zgc:85953 Protein, sortilin 1 Protein, sortilin Protein, sortilin 1 S homeolog Protein, sortilin 1a Protein, SORT1 Protein, TP01_0016 Protein, BBOV_I002730 Protein, sort1.S Protein, Sort1 Protein, sort1a Protein
- 背景
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Synonyms: Sortilin,SORT1,100 kDa NT receptor,Glycoprotein 95,Gp95,Gp95LDLCQ6,Neurotensin receptor 3,NT3NTR3,Ntr3,sortilin 1,
Description: The Sortilin is a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. - 分子量
- 79.3 kDa
- NCBI登录号
- NP_002950
- 途径
- Neurotrophin Signaling Pathway
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