SIRP AlphaV2 (AA 31-369) (Active) protein (His tag)
-
- 抗原
- SIRP AlphaV2
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 31-369
- 宿主
- 人
-
资源
- HEK-293 Cells
- 标记
- His tag
- 序列
- AA 31-369
- 产品特性
- Biotinylated Human SIRP alphaV8 / CD172a Protein, His,Avitag™
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 0.1 EU per μg by the LAL method.
-
SIRP AlphaV2 protein (His tag)
宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
SIRP AlphaV2 protein (Fc Tag)宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
SIRP AlphaV2 (AA 31-369) protein (His-Avi Tag,Biotin)宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
SIRP AlphaV2 (AA 31-369) (Active) protein (His tag,AVI tag,Biotin)宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 储存条件
- -20 °C
-
- 抗原
- SIRP AlphaV2
- 背景
- Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
- 分子量
- 39.0 kDa
-
