Fusion Glycoprotein Protein (F) (AA 27-487) (His tag)
F
宿主: Nipah Virus (NiV)
宿主: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
Active
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- 抗原 See all Fusion Glycoprotein (F) products
- Fusion Glycoprotein (F)
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 27-487
- 宿主
- Nipah Virus (NiV)
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资源
- HEK-293 Cells
- 标记
- This Fusion Glycoprotein protein is labelled with His tag.
- 原理
- Nipah virus Fusion glycoprotein, His Tag
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS
- 储存条件
- -20 °C
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- 抗原
- Fusion Glycoprotein (F)
- 别名
- Fusion glycoprotein (F 产品)
- 物质类
- Viral Protein
- 背景
- Hendra virus (HeV) and Nipah virus (NiV) are henipaviruses discovered in the mid-to late 1990s that possess a broad host tropism and are known to cause severe and often fatal disease in both humans and animals. HeV and NiV infect host cells through the coordinated efforts of two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the fusion (F) glycoprotein to execute membrane fusion. G is a type II homotetrameric transmembrane protein responsible for binding to ephrinB2 or ephrinB3 (ephrinB2/B3) receptors. F is a homotrimeric type I transmembrane protein that is synthesized as a premature F0 precursor and cleaved by cathepsin L during endocytic recycling to yield the mature, disulfide-linked, F1 and F2 subunits. Upon binding to ephrinB2/B3, NiV G undergoes conformational changes leading to F triggering and insertion of the F hydrophobic fusion peptide into the target membrane. Subsequent refolding into the more stable post-fusion F conformation drives merger of the viral and host membranes to form a pore for genome delivery to the cell cytoplasm.
- 分子量
- 55.9 kDa
- NCBI登录号
- NP_112026
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