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EPH Receptor A4 Protein (EPHA4) (AA 20-547) (His tag)

EPHA4 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
产品编号 ABIN6950965
发货至: 中国
  • 抗原 See all EPH Receptor A4 (EPHA4) 蛋白
    EPH Receptor A4 (EPHA4)
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    AA 20-547
    宿主
    • 17
    • 3
    • 2
    • 1
    资源
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    HEK-293 Cells
    标记
    This EPH Receptor A4 protein is labelled with His tag.
    纯度
    >95 % as determined by SDS-PAGE.
    内毒素水平
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product EPHA4 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    PBS, pH 7.4
    储存条件
    -20 °C
  • 抗原
    EPH Receptor A4 (EPHA4)
    别名
    EphA4 (EPHA4 产品)
    背景
    Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
    分子量
    60.3 kDa
    NCBI登录号
    NP_004429
    途径
    RTK signaling
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