CTDSP1 Protein, NIF3 Protein, NLI-IF Protein, NLIIF Protein, SCP1 Protein, fj83f12 Protein, im:7141428 Protein, wu:fj83f12 Protein, zgc:113169 Protein, GIP Protein, Nif3 Protein, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Protein, CTD small phosphatase 1 Protein, carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Protein, CTDSP1 Protein, Ctdsp1 Protein, ctdsp1 Protein, HCAG_04820 Protein, CTRG_06220 Protein
背景
Carboxy-terminal domain, RNA polymerase II, polypeptide A phosphatase 1, also known as CTDSP1, is a class 2C phosphatase with activity dependent on the conserved DxD motif. CTDSP1 preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Also it negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recombinant human CTDSP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Carboxy-terminal domain, RNA polymerase II, polypeptide A phosphatase 1, NLIIF, SCP1, NIF3. NCBI no.: NP_872580