BcDNA:GM23968 Protein, CG16792 Protein, Deb Protein, Deb-B Protein, DebB Protein, Dmel\\CG16792 Protein, dF Protein, deb-b Protein, snRNP-F Protein, sm-f Protein, smf Protein, snrpfl Protein, SMF Protein, Sm-F Protein, SmF Protein, 2010013O18Rik Protein, sm-F Protein, Small ribonucleoprotein particle protein SmF Protein, small nuclear ribonucleoprotein polypeptide F Protein, small nuclear ribonucleoprotein polypeptide F S homeolog Protein, SmF Protein, SNRPF Protein, snrpf Protein, Snrpf Protein, snrpf.S Protein
背景
Small nuclear ribonucleoprotein polypeptide F, also known SNRPF, belongs to the snRNP Sm proteins family. There are at least seven isoforms, E, F, G, D1, D2, D3 and B/B. This class of common proteins plays an essential role in the biogenesis of the snRNPs. In addition, these proteins represent the major targets for the so-called anti-Sm auto-antibodies which are diagnostic for systemic lupus erythematosus (SLE). SNRPF aid in the cytoplasmic construction of the UsnRNPs by binding to aconserved Sm site on UsnRNA and forming a stable snRNP core complex. Recombinant human SNRPF protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Small nuclear ribonucleoprotein polypeptide F, Sm-F, SMF, PBSCF. NCBI no.: NP_003086