Superoxide dismutase copper chaperone Protein (AA 1-274) (His tag)
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- 抗原 See all Superoxide dismutase copper chaperone (CCS) 蛋白
- Superoxide dismutase copper chaperone (CCS) (Copper Chaperone For Superoxide Dismutase (CCS))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-274
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宿主
- 人
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资源
- 大肠杆菌(E. Coli)
- 标记
- This Superoxide dismutase copper chaperone protein is labelled with His tag.
- 应用范围
- SDS-PAGE (SDS)
- 产品特性
- CCS, 1-274aa, Human, His tag, E.coli
- 纯度
- > 90 % by SDS - PAGE
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/ml (determined by Bradford assay)
- 缓冲液
- Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl 1mM DTT, 10% glycerol
- 储存条件
- 4 °C
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- 抗原
- Superoxide dismutase copper chaperone (CCS) (Copper Chaperone For Superoxide Dismutase (CCS))
- 别名
- CCS (CCS 产品)
- 别名
- ccs Protein, MGC82563 Protein, CCS Protein, DDBDRAFT_0189222 Protein, DDBDRAFT_0238038 Protein, DDB_0189222 Protein, DDB_0238038 Protein, ATCCS Protein, COPPER/ZINC SUPEROXIDE DISMUTASE COPPER CHAPERONE Protein, F5O11.26 Protein, F5O11_26 Protein, copper chaperone for SOD1 Protein, Ccsd Protein, copper chaperone for superoxide dismutase L homeolog Protein, copper chaperone for superoxide dismutase Protein, copper chaperone for SOD1 Protein, ccs.L Protein, ccs Protein, CCS Protein, LOC552629 Protein, Ccs Protein
- 背景
- CCS is essential for the incorporation of copper into SOD-1, and therefore is necessary for its enzymatic activity. CCS prevents copper ions from binding to intracellular copper scavengers and provides the SOD-1 enzyme with the necessary copper cofactor. CCS escorts copper only to SOD-1 and fails to deliver copper to proteins in the mitochondria, nucleus or secretory pathway. While many tissues express CCS, the chaperone is most abundant in the kidney, liver and Purkinje cells in the neuropil of the central nervous system. Recombinant human CCS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Copper chaperone for superoxide dismutase,. NCBI no.: NP_005116
- 分子量
- 31.2 kDa (294aa), confirmed by MALDI-TOF
- 途径
- Transition Metal Ion Homeostasis
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