hint Protein, pkci-1 Protein, prkcnh1 Protein, HINT Protein, NMAN Protein, PKCI-1 Protein, PRKCNH1 Protein, AA673479 Protein, Hint Protein, Ipk1 Protein, Pkci Protein, Prkci Protein, zgc:103764 Protein, CHPKCI Protein, HINTZ Protein, PKCIZ Protein, histidine triad nucleotide binding protein 1 Protein, histidine triad nucleotide binding protein 1 S homeolog Protein, histidine triad nucleotide binding protein 1-Z Protein, Histidine triad nucleotide-binding protein 1 Protein, HINT1 Protein, hint1 Protein, Hint1 Protein, hint1.S Protein, HINT1Z Protein, hint-1 Protein
背景
HINT1, also known as Histidine triad nucleotide-binding protein 1, is a member of superfamily named for a near C-terminal HXHXHXX motif (H:Histidine, X:a hydrophobic amino acid) positioned at the alpha-phosphate of nucleotide substrates. This protein hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2. Although it was originally thought to be a protein kinase C inhibitor and act as a haplod-insufficient tumor suppressor including spontaneous tumor formation in Hint+/- and Hint-/- , its actual physiologic function is not known. Recombinant human HINT1 protein was expressed in E.coli and purified by using conventional chromatography. Synonyms: Histidine triad nucleotide-binding protein 1, HINT, PKCI-1, PRKCNH1, Histidine triad nucleotide-binding protein 1 Adenosine 5' monophosphoramidase, HINT 1, Histidine triad nucleotide binding protein 1, PKCI 1, PKCI1, Protein kinase C inhibitor 1, Protein kinase C interacting protein 1. NCBI no.: NP_005331