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Ataxin 3 Protein (ATXN3) (AA 1-370)

ATXN3 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % by SDS - PAGE SDS
产品编号 ABIN666777
发货至: 中国
  • 抗原 See all Ataxin 3 (ATXN3) 蛋白
    Ataxin 3 (ATXN3)
    蛋白类型
    Recombinant
    产品特性
    AA 1-370
    宿主
    • 5
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    • 1
    • 1
    资源
    • 2
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    • 1
    大肠杆菌(E. Coli)
    应用范围
    SDS-PAGE (SDS)
    产品特性
    Ataxin 3 , 1-370aa, Human, Recombinant, E.coli
    纯度
    > 90 % by SDS - PAGE
    Top Product
    Discover our top product ATXN3 蛋白
  • 限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/ml (determined by Bradford assay)
    缓冲液
    Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 2mM DTT, 50mM NaCl, 10% glycerol.
    储存条件
    4 °C
  • 抗原
    Ataxin 3 (ATXN3)
    别名
    Ataxin 3 (ATXN3 产品)
    别名
    Mjd Protein, zgc:56323 Protein, ATXN3 Protein, at3 Protein, jos Protein, mjd Protein, atx3 Protein, mjd1 Protein, sca3 Protein, ataxin-3 Protein, MJD1 Protein, MGC83584 Protein, AT3 Protein, ATX3 Protein, JOS Protein, MJD Protein, SCA3 Protein, 2210008M02Rik Protein, AI463012 Protein, AI647473 Protein, Sca3 Protein, Rsca3 Protein, ataxin 3 Protein, ataxin 3 L homeolog Protein, ataxin-3 Protein, atxn3 Protein, ATXN3 Protein, atxn3.L Protein, MICPUN_104046 Protein, MICPUCDRAFT_46658 Protein, Atxn3 Protein
    背景
    Ataxin 3 is also known as Machado-Joseph disease protein 1. Machado–Joseph disease is one of several hereditary autosomal dominant neurodegenerative disorders. This protein contains trinucleotide CAG repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. Ataxin 3 interacts with the major histone acetyltransferases cAMP-response-element binding protein (CREB)-binding protein, p300, and p300/CREB-binding protein-associated factor and inhibits transcription by these coactivators. Also, ataxin-3 is a proteasome-associated factor that mediates the degradation of ubiquitinated proteins. Recombinant human Ataxin-3 was expressed in E.coli and purified by using conventional chromatography. Synonyms: Ataxin 3, ATX3, MJD, MJD1, SCA3, ATXN3, JOS, ATXN3, AT3, EC 3.4.22., Josephin, Machado Joseph disease, Machado Joseph disease protein 1, Machado-Joseph disease protein 1 homolog, MJD gene, Rsca3, SCA3 gene, Spinocerebellar ataxia type 3 protein,. NCBI no.: AAH33711
    分子量
    42.4 kDa (370aa), confirmed by MALDI-TOF.
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