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SEMA7A Protein (AA 45-648) (hIgG-His-tag)

SEMA7A 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % by SDS - PAGE SDS
产品编号 ABIN6388152
发货至: 中国
  • 抗原 See all SEMA7A 蛋白
    SEMA7A (Semaphorin 7A, GPI Membrane Anchor (John Milton Hagen Blood Group) (SEMA7A))
    蛋白类型
    Recombinant
    产品特性
    AA 45-648
    宿主
    • 5
    • 4
    资源
    • 3
    • 2
    • 2
    • 1
    • 1
    Baculovirus infected Insect Cells
    标记
    This SEMA7A protein is labelled with hIgG-His-tag.
    应用范围
    SDS-PAGE (SDS)
    序列
    ADPQGHLRSG PRIFAVWKGH VGQDRVDFGQ TEPHTVLFHE PGSSSVWVGG RGKVYLFDFP EGKNASVRTV NIGSTKGSCL DKRDCENYIT LLERRSEGLL ACGTNARHPS CWNLVNGTVV PLGEMRGYAP FSPDENSLVL FEGDEVYSTI RKQEYNGKIP RFRRIRGESE LYTSDTVMQN PQFIKATIVH QDQAYDDKIY YFFREDNPDK NPEAPLNVSR VAQLCRGDQG GESSLSVSKW NTFLKAMLVC SDAATNKNFN RLQDVFLLPD PSGQWRDTRV YGVFSNPWNY SAVCVYSLGD IDKVFRTSSL KGYHSSLPNP RPGKCLPDQQ PIPTETFQVA DRHPEVAQRV EPMGPLKTPL FHSKYHYQKV AVHRMQASHG ETFHVLYLTT DRGTIHKVVE PGEQEHSFAF NIMEIQPFRR AAAIQTMSLD AERRKLYVSS QWEVSQVPLD LCEVYGGGCH GCLMSRDPYC GWDQGRCISI YSSERSVLQS INPAEPHKEC PNPKPDKAPL QKVSLAPNSR YYLSCPMESR HATYSWRHKE NVEQSCEPGH QSPNCILFIE NLTAQQYGHY FCEAQEGSYF REAQHWQLLP EDGIMAEHLL GHACALALEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH
    纯度
    > 90 % by SDS - PAGE
    内毒素水平
    < 1.0 EU per 1ug of protein (determined by LAL method)
    Top Product
    Discover our top product SEMA7A 蛋白
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
  • 抗原
    SEMA7A (Semaphorin 7A, GPI Membrane Anchor (John Milton Hagen Blood Group) (SEMA7A))
    别名
    SEMA7A (SEMA7A 产品)
    别名
    2900057C09Rik Protein, CDw108 Protein, H-Sema-L Protein, M-Sema-L Protein, Semal Protein, CD108 Protein, H-SEMA-K1 Protein, JMH Protein, SEMAK1 Protein, SEMAL Protein, sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A Protein, semaphorin 7A (John Milton Hagen blood group) Protein, Sema7a Protein, SEMA7A Protein
    背景
    SEMA7A, also known as semaphorin-7A isoform 1, is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. It promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. It plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. It promotes production of proinflammatory cytokines by monocytes and macrophages. Recombinant human SEMA7A, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
    分子量
    95.7kDa (846aa) 70-100kDa (SDS-PAGE under reducing conditions)
    NCBI登录号
    NP_003603
    UniProt
    O75326
    途径
    Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Cell Size
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