BSND Protein, BART Protein, DFNB73 Protein, Bartter syndrome, infantile, with sensorineural deafness (Barttin) Protein, barttin CLCNK type accessory beta subunit Protein, BSND Protein, Bsnd Protein
背景
BSND is an essential beta subunit for CLC chloride channels. These heteromeric channels localize to basolateral membranes of renal tubules and of potassium-secreting epithelia of the inner ear. Mutations in this BSND have been associated with Bartter syndrome with sensorineural deafness. Recombinant human BSND protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.