ITGA4/ITGB7 Protein (AA 34-977) (His tag)
ITGA4 / ITGB7
宿主: 人
宿主: HEK-293 Cells
Recombinant
>90 % as determined by SDS-PAGE.
Active
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- 抗原 See all ITGA4/ITGB7 (ITGA4 / ITGB7) products
- ITGA4/ITGB7 (ITGA4 / ITGB7) (Integrin Alpha4-Beta7 (ITGA4 / ITGB7))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 34-977
- 宿主
- 人
- 资源
- HEK-293 Cells
- 标记
- This ITGA4/ITGB7 protein is labelled with His tag.
- 序列
- AA 34-977
- 纯度
- >90 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- 50 mM Tris, 100 mM NaCl, pH 7.5
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
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- 抗原
- ITGA4/ITGB7 (ITGA4 / ITGB7) (Integrin Alpha4-Beta7 (ITGA4 / ITGB7))
- 别名
- Integrin alpha 4 beta 7 (ITGA4 / ITGB7 产品)
- 别名
- CD49D Protein, integrin alpha 4 Protein, Itga4 Protein
- 背景
- Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer's patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).
- 分子量
- 111.4 kDa (ITGA4) & 81.8 kDa (ITGB7)
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