BTNL2 Protein (AA 26-457) (Fc Tag)
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- 抗原 See all BTNL2 蛋白
- BTNL2 (Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2))
- 蛋白类型
- Recombinant
- 产品特性
- AA 26-457
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宿主
- 小鼠
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资源
- CHO Cells
- 标记
- This BTNL2 protein is labelled with Fc Tag.
- 原理
- BTNL2 (mouse):Fc (mouse) (rec.)
- 特异性
- The extracellular domain of mouse BTNL2 (aa 26-457) is fused to the N-terminus of the Fc region of mouse IgG2a.
- 产品特性
- Protein. The extracellular domain of mouse BTNL2 (aa 26-457) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analysis, to sporadic inclusion body myositis and sarcoidosis. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. BTNL2-Ig fusion protein was shown to recognize a putative receptor whose expression on B and T cells was significantly enhanced after activation. It inhibited T cell proliferation and TCR activation of NFAT, NF-kappaB and AP-1 signaling pathways. BTNL2 is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.
- 纯度
- >98 % (SDS-PAGE)
- 内毒素水平
- <0.06EU/μg protein (LAL test, Lonza).
- Biological Activity Comment
- A butyrophilin-like molecule that functions to inhibit T cell activation.
- Top Product
- Discover our top product BTNL2 蛋白
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Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2) (AA 1-454) protein (Strep Tag)
Crystallography grade BTNL2 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB
Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2) (AA 24-455) protein (His tag)Crystallography grade BTNL2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB, Crys
Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2) (AA 24-454) protein (His tag)Crystallography grade BTNL2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB, Crys
Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2) (AA 1-455) protein (rho-1D4 tag)Crystallography grade BTNL2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 浓度
- Lot specific
- 缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
- 注意事项
- Avoid freeze/thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- 抗原
- BTNL2 (Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2))
- 别名
- BTNL2 (BTNL2 产品)
- 别名
- BTL-II Protein, HSBLMHC1 Protein, SS2 Protein, Ng9 Protein, BTLN2 Protein, Btl2 Protein, Gm315 Protein, NG9 Protein, BTNL2 Protein, butyrophilin like 2 Protein, butyrophilin-like 2 Protein, butyrophilin-like 2 (MHC class II associated) Protein, butyrophilin-like protein 2 Protein, BTNL2 Protein, Btnl2 Protein, LOC100348151 Protein
- 背景
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Alternate Names/Synonyms: Butyrophilin-like Protein 2
Product Description: Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analysis, to sporadic inclusion body myositis and sarcoidosis. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. BTNL2-Ig fusion protein was shown to recognize a putative receptor whose expression on B and T cells was significantly enhanced after activation. It inhibited T cell proliferation and TCR activation of NFAT, NF-kappaB and AP-1 signaling pathways. BTNL2 is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.
- NCBI登录号
- NP_524574
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