BMP2 Protein (AA 289-396) (Fc Tag)
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- 抗原 See all BMP2 蛋白
- BMP2 (Bone Morphogenetic Protein 2 (BMP2))
- 蛋白类型
- Recombinant
- 产品特性
- AA 289-396
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宿主
- 人
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资源
- CHO Cells
- 标记
- This BMP2 protein is labelled with Fc Tag.
- 原理
- BMP-2 (human):Fc (human) (rec.) (non-lytic)
- 特异性
- The extracellular domain of human BMP-2 (aa 289-396) is fused to the N-terminus of the Fc region of a mutant human IgG1.
- 产品特性
- Protein. The extracellular domain of human BMP-2 (aa 289-396) is fused to the N-terminus of the Fc region of a mutant human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMP-RIA or BMP-RIB) and a type II receptor (BMP-RII or Activin RIIB). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.
- 纯度
- >98 % (SDS-PAGE)
- 内毒素水平
- <0.06EU/μg protein (LAL test, Lonza).
- Biological Activity Comment
- Shows the biological function of the BMP-2 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
- Top Product
- Discover our top product BMP2 蛋白
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Bone Morphogenetic Protein 2 (BMP2) (AA 283-396) (Active) protein
BMP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as analyzed by non-reducing SDS-PAGE. Active
Bone Morphogenetic Protein 2 (BMP2) (AA 283-396) protein (His-IF2DI Tag)BMP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Bone Morphogenetic Protein 2 (BMP2) (AA 283-396) proteinBMP2 宿主: 人, 犬, 小鼠, 大鼠, 猕猴 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE
Bone Morphogenetic Protein 2 (BMP2) (AA 1-396) protein (GST tag)BMP2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Bone Morphogenetic Protein 2 (BMP2) (AA 283-396) protein (GST tag)BMP2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Bone Morphogenetic Protein 2 (BMP2) (AA 231-330) protein (GST tag)BMP2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Bone Morphogenetic Protein 2 (BMP2) (AA 284-396) proteinBMP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >92 % as determined by SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 浓度
- Lot specific
- 缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
- 注意事项
- Avoid freeze/thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- 抗原
- BMP2 (Bone Morphogenetic Protein 2 (BMP2))
- 别名
- BMP-2 (BMP2 产品)
- 别名
- BDA2 Protein, BMP2A Protein, AI467020 Protein, Bmp2a Protein, BMP-2 Protein, xBMP-2 Protein, xbmp2 Protein, BMP2 Protein, bmp2a Protein, bmp2 Protein, wu:fc59d09 Protein, bone morphogenetic protein 2 Protein, bone morphogenetic protein 2 L homeolog Protein, Bone morphogenetic protein 2 Protein, bone morphogenetic protein 2a Protein, BMP2 Protein, Bmp2 Protein, bmp2.L Protein, bmp2 Protein, bmp2a Protein
- 背景
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Alternate Names/Synonyms: BMP2, Bone Morphogenetic Protein 2
Product Description: Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMP-RIA or BMP-RIB) and a type II receptor (BMP-RII or Activin RIIB). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.
- NCBI登录号
- NP_001191
- 途径
- Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Growth Factor Binding, Positive Regulation of fat Cell Differentiation
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