HCV E2 Protein (AA 482-671) (His tag)
HCV E2
宿主: Hepatitis C Virus (HCV)
宿主: 大肠杆菌（E. Coli）
Recombinant
> 80 % by SDS - PAGE
SDS
1 image
-
- 抗原 See all HCV E2 蛋白
- HCV E2 (Hepatitis C Virus Envelope Protein E2 (HCV E2))
- 蛋白类型
- Recombinant
- 产品特性
- AA 482-671
-
宿主
- Hepatitis C Virus (HCV)
-
资源
- 大肠杆菌（E. Coli）
- 标记
- This HCV E2 protein is labelled with His tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSERPY CWHYPPRPCG IVPAKSVCGP VYCFTPSPVV VGTTDRSGAP TYSWGANDTD VFVLNNTRPP LGNWFGCTWM NSTGFTKVCG APPCVIGGVG NNTLLCPTDC FRKHPEATYS RCGSGPWITP RCMVDYPYRL WHYPCTINYT IFKVRMYVGG VEHRLEAACN WTRGERCDLE DRDRSELSPL LLSTTQ
- 纯度
- > 80 % by SDS - PAGE
- Top Product
- Discover our top product HCV E2 蛋白
-
Hepatitis C Virus Envelope Protein E2 (HCV E2) (AA 383-663) protein (His tag)
HCV E2 宿主: Virus 宿主: 人细胞 Recombinant SDS
Hepatitis C Virus Envelope Protein E2 (HCV E2) protein (His tag)HCV E2 宿主: Hepatitis C Virus (HCV) 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE.
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
-
Denatured
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 0.25 mg/mL
- 缓冲液
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.4M urea, 10 % glycerol
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
-
- 抗原
- HCV E2 (Hepatitis C Virus Envelope Protein E2 (HCV E2))
- 别名
- HCV-E2 (HCV E2 产品)
- 物质类
- Viral Protein
- 背景
- E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. Recombinant HCV(Hepatitis C Virus) E2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
- 分子量
- 25.4 kDa (226aa)
- NCBI登录号
- NP_671491
-
You are here:
