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CAMLG Protein (AA 1-189) (His tag)

CAMLG 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 85 % by SDS - PAGE SDS
产品编号 ABIN5853110
发货至: 中国
  • 抗原 See all CAMLG 蛋白
    CAMLG (Calcium Modulating Ligand (CAMLG))
    蛋白类型
    Recombinant
    产品特性
    AA 1-189
    宿主
    • 6
    • 2
    • 1
    资源
    • 4
    • 2
    • 2
    • 1
    大肠杆菌(E. Coli)
    标记
    This CAMLG protein is labelled with His tag.
    应用范围
    SDS-PAGE (SDS)
    序列
    MGSSHHHHHH SSGLVPRGSH MGSMESMAVA TDGGERPGVP AGSGLSASQR RAELRRRKLL MNSEQRINRI MGFHRPGSGA EEESQTKSKQ QDSDKLNSLS VPSVSKRVVL GDSVSTGTTD QQGGVAEVKG TQLGDKLDSF IKPPECSSDV NLELRQRNRG DLTADSVQRG SRHGLEQYLS RFEEAMKLRK QLISEKPSQE DGNTTEEFDS FR
    纯度
    > 85 % by SDS - PAGE
    Top Product
    Discover our top product CAMLG 蛋白
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.5 mg/mL
    缓冲液
    Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.15M NaCl, 10 % glycerol
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
  • 抗原
    CAMLG (Calcium Modulating Ligand (CAMLG))
    别名
    CAMLG (CAMLG 产品)
    别名
    MGC53900 Protein, CAML Protein, AI385748 Protein, Camlg Protein, Caml Protein, calcium modulating ligand L homeolog Protein, calcium modulating ligand Protein, camlg.L Protein, CAMLG Protein, camlg Protein, Caml Protein, Camlg Protein
    背景
    The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. CAMLG functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. Recombinant human CAMLG protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
    分子量
    23.2 kDa (212aa), confirmed by MALDI-TOF
    NCBI登录号
    NP_001736
    UniProt
    P49069
    途径
    EGFR Signaling Pathway
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