2010004G08Rik Protein, 2010005N21Rik Protein, 3010027N18Rik Protein, FGFIBP Protein, FIBP-1 Protein, fibp Protein, zgc:64086 Protein, aFGF intracellular-binding protein B Protein, fibpl Protein, zgc:103503 Protein, fibroblast growth factor (acidic) intracellular binding protein Protein, FGF1 intracellular binding protein Protein, fibroblast growth factor (acidic) intracellular binding protein a Protein, fibroblast growth factor (acidic) intracellular binding protein L homeolog Protein, fibroblast growth factor (acidic) intracellular binding protein b Protein, Fibp Protein, FIBP Protein, fibpa Protein, fibp.L Protein, fibpb Protein
背景
Acidic fibroblast growth factor intracellular-binding protein isoform a, also known as FIBP, is a member of Fibroblast growth factors (FGFs) represent a family. FGF activity influences development, adult tissue homeostasis, angiogenesis and cancer progression. FIBP is a 364 amino acid protein that binds to internalized FGF-1 and is thought to be involved in mitogenic function of FGF-1. FIBP localizes to the nucleus and is highly expressed in heart, skeletal muscle and pancreas and at lower levels in brain, placenta, liver and kidney. Recombinant human FIBP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.