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- 抗原 See all SLC26A5 蛋白
- SLC26A5 (Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5))
- 蛋白类型
- Recombinant
- 产品特性
- AA 501-744
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宿主
- 人
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资源
- 酵母菌
- 标记
- This SLC26A5 protein is labelled with His tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- YRTQSPSYKV LGKLPETDVY IDIDAYEEVK EIPGIKIFQI NAPIYYANSD LYSNALKRKT GVNPAVIMGA RRKAMRKYAK EVGNANMANA TVVKADAEVD GEDATKPEEE DGEVKYPPIV IKSTFPEEMQ RFMPPGDNVH TVILDFTQVN FIDSVGVKTL AGIVKEYGDV GIYVYLAGCS AQVVNDLTRN RFFENPALWE LLFHSIHDAV LGSQLREALA EQEASAPPSQ EDLEPNATPA TPEA
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product SLC26A5 蛋白
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Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) (AA 1-447) protein (GST tag)
SLC26A5 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) (AA 1-744) protein (Strep Tag)Crystallography grade SLC26A5 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) (AA 1-744) protein (Strep Tag)Crystallography grade SLC26A5 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) (AA 501-744) protein (His tag)Crystallography grade SLC26A5 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) (AA 501-744) protein (His tag)Crystallography grade SLC26A5 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- SLC26A5 (Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5))
- 别名
- S26A5 (SLC26A5 产品)
- 别名
- pres Protein, fb73d12 Protein, fb74g12 Protein, wu:fb73d12 Protein, wu:fb74g12 Protein, DFNB61 Protein, PRES Protein, Pres Protein, prestin Protein, solute carrier family 26 (anion exchanger), member 5 Protein, solute carrier family 26 member 5 Protein, solute carrier family 26, member 5 Protein, slc26a5 Protein, SLC26A5 Protein, Slc26a5 Protein
- 背景
- Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the mbrane in response to changes in the transmbrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma mbrane. The area decreases when the anion is near the cytoplasmic face of the mbrane (short state), and increases when the ion has crossed the mbrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the mbrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site .
- 分子量
- 28.96 kDa
- UniProt
- P58743
- 途径
- Sensory Perception of Sound, Dicarboxylic Acid Transport
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