PSME3 Protein (PSME3) (AA 2-252, partial) (GST tag)
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- 抗原 See all PSME3 蛋白
- PSME3
- 蛋白类型
- Recombinant
- 产品特性
- partial, AA 2-252
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宿主
- 人
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资源
- 大肠杆菌(E. Coli)
- 标记
- This PSME3 protein is labelled with GST tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- ASLLKVDQEV KLKVDSFRER ITSEAEDLVA NFFPKKLLEL DSFLKEPILN IHDLTQIHSD MNLPVPDPIL LTNSHDGLDG PTYKKRRLDE CEEAFQGTKV FVMPNGMLKS NQQLVDIIEK VKPEIRLLIE KCNTVKMWVQ LLIPRIEDGN NFGVSIQEET VAELRTVESE AASYLDQISR YYITRAKLVS KIAKYPHVED YRRTVTEIDE KEYISLRLII SELRNQYVTL HDMILKNIEK IKRPRSSNAE T
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product PSME3 蛋白
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- PSME3
- 别名
- PSME3 (PSME3 产品)
- 别名
- AA410043 Protein, AU020960 Protein, Ki Protein, PA28gamma Protein, REGgamma Protein, pa28g Protein, Ab2-371 Protein, PA28-gamma Protein, PA28G Protein, REG-GAMMA Protein, psme3b Protein, proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) Protein, proteasome activator subunit 3 Protein, proteasome activator subunit 3 S homeolog Protein, Psme3 Protein, PSME3 Protein, psme3.S Protein
- 背景
- Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.
- 分子量
- 56.5 kDa
- UniProt
- P61289
- 途径
- Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Hepatitis C, Synthesis of DNA
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