GPR161 Protein (AA 1-28, Extracellular, partial) (GST tag)
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- 抗原 See all GPR161 蛋白
- GPR161 (G Protein-Coupled Receptor 161 (GPR161))
- 蛋白类型
- Recombinant
- 产品特性
- Extracellular, AA 1-28, partial
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宿主
- 人
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资源
- 大肠杆菌(E. Coli)
- 标记
- This GPR161 protein is labelled with GST tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MSLNSSLSCR KELSNLTEEE GGEGGVII
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product GPR161 蛋白
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- GPR161 (G Protein-Coupled Receptor 161 (GPR161))
- 别名
- GP161 (GPR161 产品)
- 别名
- RE2 Protein, Gm208 Protein, Gm208Gpr Protein, vl Protein, RGD1563245 Protein, si:bz20i5.4 Protein, si:rp71-20i5.4 Protein, G protein-coupled receptor 161 Protein, GPR161 Protein, Gpr161 Protein, gpr161 Protein
- 背景
- Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is roved from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown .
- 分子量
- 30.4 kDa
- UniProt
- Q8N6U8
- 途径
- cAMP Metabolic Process
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