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GPR161 Protein (AA 1-28, Extracellular, partial) (GST tag)

GPR161 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % SDS
产品编号 ABIN5712333
发货至: 中国
  • 抗原 See all GPR161 蛋白
    GPR161 (G Protein-Coupled Receptor 161 (GPR161))
    蛋白类型
    Recombinant
    产品特性
    Extracellular, AA 1-28, partial
    宿主
    • 5
    • 2
    资源
    • 3
    • 2
    • 2
    大肠杆菌(E. Coli)
    标记
    This GPR161 protein is labelled with GST tag.
    应用范围
    SDS-PAGE (SDS)
    序列
    MSLNSSLSCR KELSNLTEEE GGEGGVII
    纯化方法
    SDS-PAGE
    纯度
    > 90 %
    Top Product
    Discover our top product GPR161 蛋白
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.1-2 mg/mL
    缓冲液
    20 mM Tris-HCl based buffer, pH 8.0
    储存条件
    -80 °C,4 °C,-20 °C
    储存方法
    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 抗原
    GPR161 (G Protein-Coupled Receptor 161 (GPR161))
    别名
    GP161 (GPR161 产品)
    别名
    RE2 Protein, Gm208 Protein, Gm208Gpr Protein, vl Protein, RGD1563245 Protein, si:bz20i5.4 Protein, si:rp71-20i5.4 Protein, G protein-coupled receptor 161 Protein, GPR161 Protein, Gpr161 Protein, gpr161 Protein
    背景
    Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is roved from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown .
    分子量
    30.4 kDa
    UniProt
    Q8N6U8
    途径
    cAMP Metabolic Process
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