MOB1A Protein (AA 2-216) (His-SUMO Tag)
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- 抗原 See all MOB1A (MOBKL1B) 蛋白
- MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))
- 蛋白类型
- Recombinant
- 产品特性
- AA 2-216
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This MOB1A protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- SFLFSSRSSK TFKPKKNIPE GSHQYELLKH AEATLGSGNL RQAVMLPEGE DLNEWIAVNT VDFFNQINML YGTITEFCTE ASCPVMSAGP RYEYHWADGT NIKKPIKCSA PKYIDYLMTW VQDQLDDETL FPSKIGVPFP KNFMSVAKTI LKRLFRVYAH IYHQHFDSVM QLQEEAHLNT SFKHFIFFVQ EFNLIDRREL APLQELIEKL GSKDR
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product MOBKL1B 蛋白
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MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B) (AA 1-216) protein (His tag)
MOBKL1B 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B) (AA 1-216) protein (GST tag)MOBKL1B 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B) (AA 2-216) protein (His tag)Crystallography grade MOBKL1B 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B) protein (Myc-DYKDDDDK Tag)MOBKL1B 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))
- 别名
- MOB1A (MOBKL1B 产品)
- 别名
- mob1 Protein, mob4b Protein, MOB1A Protein, MOBK1B Protein, MOB1 Protein, mats1 Protein, mobk1b Protein, mobkl1b Protein, MOBKL1B Protein, wu:fv69d04 Protein, zgc:56189 Protein, C2orf6 Protein, MATS1 Protein, Mob4B Protein, 4022402H07Rik Protein, MOB4B Protein, Mobk1b Protein, Mobkl1b Protein, MOB kinase activator 1A L homeolog Protein, MOB kinase activator 1A Protein, MOB kinase activator 1A pseudogene Protein, mob1a.L Protein, MOB1A Protein, mob1a Protein, LOC712156 Protein, Mob1a Protein
- 背景
- Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.
- 分子量
- 40.9 kDa
- UniProt
- Q9H8S9
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