Sorting Nexin 1 Protein (SNX1) (AA 1-522, full length) (His-SUMO Tag)
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- 抗原 See all Sorting Nexin 1 (SNX1) 蛋白
- Sorting Nexin 1 (SNX1)
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-522, full length
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This Sorting Nexin 1 protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MASGGGGCSA SERLPPPFPG LEPESEGAAG GSEPEAGDSD TEGEDIFTGA AVVSKHQSPK ITTSLLPINN GSKENGIHEE QDQEPQDLFA DATVELSLDS TQNNQKKVLA KTLISLPPQE ATNSSKPQPT YEELEEEEQE DQFDLTVGIT DPEKIGDGMN AYVAYKVTTQ TSLPLFRSKQ FAVKRRFSDF LGLYEKLSEK HSQNGFIVPP PPEKSLIGMT KVKVGKEDSS SAEFLEKRRA ALERYLQRIV NHPTMLQDPD VREFLEKEEL PRAVGTQTLS GAGLLKMFNK ATDAVSKMTI KMNESDIWFE EKLQEVECEE QRLRKLHAVV ETLVNHRKEL ALNTAQFAKS LAMLGSSEDN TALSRALSQL AEVEEKIEQL HQEQANNDFF LLAELLSDYI RLLAIVRAAF DQRMKTWQRW QDAQATLQKK REAEARLLWA NKPDKLQQAK DEILEWESRV TQYERDFERI STVVRKEVIR FEKEKSKDFK NHVIKYLETL LYSQQQLAKY WEAFLPEAKA IS
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product SNX1 蛋白
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Sorting Nexin 1 (SNX1) (AA 1-522) protein (GST tag)
SNX1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Sorting Nexin 1 (SNX1) (AA 166-275) protein (GST tag)SNX1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Sorting Nexin 1 (SNX1) (AA 146-522) protein (His tag)SNX1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % by SDS - PAGE SDS
Sorting Nexin 1 (SNX1) (AA 1-522) protein (Strep Tag)Crystallography grade SNX1 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Sorting Nexin 1 (SNX1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)SNX1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- Sorting Nexin 1 (SNX1)
- 别名
- SNX1 (SNX1 产品)
- 别名
- d254 Protein, sb:cb923 Protein, snx1 Protein, wu:fb40c08 Protein, wu:fj65g09 Protein, MGC82200 Protein, SNX1 Protein, HsT17379 Protein, VPS5 Protein, ARABIDOPSIS THALIANA SORTING NEXIN 1 Protein, ATSNX1 Protein, K16F4.11 Protein, K16F4_11 Protein, sorting nexin 1 Protein, sorting nexin 1a Protein, sorting nexin 1 L homeolog Protein, sorting nexin 1 Protein, sorting nexin-1 Protein, snx1a Protein, snx1.L Protein, SNX1 Protein, snx1 Protein, LOC100380673 Protein, Snx1 Protein
- 背景
- Involved in several stages of intracellular trafficking. Interacts with mbranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) . Acts in part as component of the retromer mbrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma mbrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor mbrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense mbrane curvature and has in vitro vesicle-to-mbrane rodeling activity . Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi . Involvent in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R . Promotes KALRN- and RHOG-dependent but retromer-independent mbrane rodeling such as lamellipodium formation, the function is dependent on GEF activity of KALRN . Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking .
- 分子量
- 75.07 kDa
- UniProt
- Q13596
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