SKP2 Protein (AA 1-424, full length) (His-SUMO Tag)
-
- 抗原 See all SKP2 蛋白
- SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))
- 蛋白类型
- Recombinant
- 产品特性
- full length, AA 1-424
-
宿主
- 人
-
资源
- 大肠杆菌（E. Coli）
- 标记
- This SKP2 protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MHRKHLQEIP DLSSNVATSF TWGWDSSKTS ELLSGMGVSA LEKEEPDSEN IPQELLSNLG HPESPPRKRL KSKGSDKDFV IVRRPKLNRE NFPGVSWDSL PDELLLGIFS CLCLPELLKV SGVCKRWYRL ASDESLWQTL DLTGKNLHPD VTGRLLSQGV IAFRCPRSFM DQPLAEHFSP FRVQHMDLSN SVIEVSTLHG ILSQCSKLQN LSLEGLRLSD PIVNTLAKNS NLVRLNLSGC SGFSEFALQT LLSSCSRLDE LNLSWCFDFT EKHVQVAVAH VSETITQLNL SGYRKNLQKS DLSTLVRRCP NLVHLDLSDS VMLKNDCFQE FFQLNYLQHL SLSRCYDIIP ETLLELGEIP TLKTLQVFGI VPDGTLQLLK EALPHLQINC SHFTTIARPT IGNKKNQEIW GIKCRLTLQK PSCL
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product SKP2 蛋白
-
S-Phase Kinase-Associated Protein 2 (SKP2) (AA 1-424) protein (GST tag)
SKP2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
S-Phase Kinase-Associated Protein 2 (SKP2) (AA 176-285) protein (GST tag)SKP2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
S-Phase Kinase-Associated Protein 2 (SKP2) (AA 1-424) protein (Strep Tag)Crystallography grade SKP2 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
S-Phase Kinase-Associated Protein 2 (SKP2) (AA 1-424) protein (Strep Tag)Crystallography grade SKP2 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
S-Phase Kinase-Associated Protein 2 (SKP2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)SKP2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
-
- 抗原
- SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))
- 别名
- SKP2 (SKP2 产品)
- 别名
- FBXL1 Protein, FBL1 Protein, FLB1 Protein, p45 Protein, RGD1562456 Protein, S-phase kinase-associated protein 2 (p45) Protein, S-phase kinase associated protein 2 Protein, Skp2 Protein, SKP2 Protein
- 背景
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration
- 分子量
- 63.73 kDa
- UniProt
- Q13309
- 途径
- Mitotic G1-G1/S Phases
-
