Vpx Protein (VPX) (AA 1-113), (full length) protein (His tag)
VPX
宿主: Human Immunodeficiency Virus (HIV)
宿主: 大肠杆菌（E. Coli）
Recombinant
> 90 %
SDS
1 image
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- 抗原 See all Vpx Protein (VPX) 蛋白
- Vpx Protein (VPX)
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-113, full length
- 宿主
- Human Immunodeficiency Virus (HIV)
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资源
- 大肠杆菌（E. Coli）
- 标记
- His tag
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MTDPRERVPP GNSGEETIGE AFEWLERTIE ALNREAVNHL PRELIFQVWQ RSWRYWHDEQ GMSASYTKYR YLCLMQKAIF THFKRGCTCW GEDMGREGLE DQGPPPPPPP GLV
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
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Vpx Protein (VPX) (AA 1-112), (full length) protein (His-SUMO Tag)
VPX 宿主: Simian Immunodeficiency Virus (SIV) 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- Vpx Protein (VPX)
- 别名
- VPX (VPX 产品)
- 别名
- vpx protein Protein, vpx Protein
- 物质类
- Viral Protein
- 背景
- Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
- 分子量
- 17.3 kDa
- UniProt
- P18099
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