RIPK2 Protein (AA 1-540, full length) (His tag)
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- 抗原 See all RIPK2 蛋白
- RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))
- 蛋白类型
- Recombinant
- 产品特性
- full length, AA 1-540
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This RIPK2 protein is labelled with His tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MNGEAICSAL PTIPYHKLAD LRYLSRGASG TVSSARHADW RVQVAVKHLH IHTPLLDSER KDVLREAEIL HKARFSYILP ILGICNEPEF LGIVTEYMPN GSLNELLHRK TEYPDVAWPL RFRILHEIAL GVNYLHNMTP PLLHHDLKTQ NILLDNEFHV KIADFGLSKW RMMSLSQSRS SKSAPEGGTI IYMPPENYEP GQKSRASIKH DIYSYAVITW EVLSRKQPFE DVTNPLQIMY SVSQGHRPVI NEESLPYDIP HRARMISLIE SGWAQNPDER PSFLKCLIEL EPVLRTFEEI TFLEAVIQLK KTKLQSVSSA IHLCDKKKME LSLNIPVNHG PQEESCGSSQ LHENSGSPET SRSLPAPQDN DFLSRKAQDC YFMKLHHCPG NHSWDSTISG SQRAAFCDHK TTPCSSAIIN PLSTAGNSER LQPGIAQQWI QSKREDIVNQ MTEACLNQSL DALLSRDLIM KEDYELVSTK PTRTSKVRQL LDTTDIQGEE FAKVIVQKLK DNKQMGLQPY PEILVVSRSP SLNLLQNKSM
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product RIPK2 蛋白
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Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (AA 1-299) (Active) protein (His-GST)
RIPK2 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (AA 1-540) protein (GST tag)RIPK2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (AA 431-540) protein (GST tag)RIPK2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (AA 1-540) protein (Strep Tag)Crystallography grade RIPK2 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) protein (Myc-DYKDDDDK Tag)RIPK2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))
- 别名
- RIPK2 (RIPK2 产品)
- 别名
- RIPK2 Protein, 2210420D18Rik Protein, CARD3 Protein, CARDIAK Protein, CCK Protein, D4Bwg0615e Protein, RICK Protein, RIP2 Protein, GIG30 Protein, receptor interacting serine/threonine kinase 2 Protein, receptor (TNFRSF)-interacting serine-threonine kinase 2 Protein, receptor-interacting serine-threonine kinase 2 Protein, RIPK2 Protein, Ripk2 Protein
- 背景
- Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagent of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
- 分子量
- 65.3 kDa
- UniProt
- O43353
- 途径
- TCR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades
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