IFIT3 Protein (AA 1-490, full length) (His-SUMO Tag)
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- 抗原 See all IFIT3 蛋白
- IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))
- 蛋白类型
- Recombinant
- 产品特性
- full length, AA 1-490
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This IFIT3 protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MSEVTKNSLE KILPQLKCHF TWNLFKEDSV SRDLEDRVCN QIESLNTEFK ATMYNLLAYI KHLDGNNEAA LECLRQAEEL IQQEHADQAE IRSLVTWGNY AWVYYHLGRL SDAQIYVDKV KQTCKKFSNP YSIEYSELDC EEGWTQLKCG RNERAKVCFE KALEEKPNNP EFSSGLAIAM YHLDNHPEKQ FSTDVLKQAI ELSPDNQYVK VLLGLKLQKM NKEAEGEQFV EEALEKSPCQ TDVLRSAAKF YRRKGDLDKA IELFQRVLES TPNNGYLYHQ IGCCYKAKVR QMQNTGESEA SGNKEMIEAL KQYAMDYSNK ALEKGLNPLN AYSDLAEFLE TECYQTPFNK EVPDAEKQQS HQRYCNLQKY NGKSEDTAVQ HGLEGLSISK KSTDKEEIKD QPQNVSENLL PQNAPNYWYL QGLIHKQNGD LLQAAKCYEK ELGRLLRDAP SGIGSIFLSA SELEDGSEEM GQGAVSSSPR ELLSNSEQLN
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product IFIT3 蛋白
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Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (AA 1-490) protein (GST tag)
IFIT3 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (AA 392-490) protein (GST tag)IFIT3 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (AA 1-490) protein (His tag)IFIT3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)IFIT3 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)IFIT3 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))
- 别名
- IFIT3 (IFIT3 产品)
- 别名
- DKFZp469G2233 Protein, CIG-49 Protein, GARG-49 Protein, IFI60 Protein, IFIT4 Protein, IRG2 Protein, ISG60 Protein, P60 Protein, RIG-G Protein, Ifi49 Protein, P49 Protein, IFIT-3 Protein, interferon induced protein with tetratricopeptide repeats 3 Protein, interferon-induced protein with tetratricopeptide repeats 3 Protein, IFIT3 Protein, Ifit3 Protein
- 背景
- IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
- 分子量
- 71.9 kDa
- UniProt
- O14879
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