HDAC3 Protein (AA 1-428, full length) (His-SUMO Tag)
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- 抗原 See all HDAC3 蛋白
- HDAC3 (Histone Deacetylase 3 (HDAC3))
- 蛋白类型
- Recombinant
- 产品特性
- full length, AA 1-428
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This HDAC3 protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP YQASQHDMCR FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL FEFCSRYTGA SLQGATQLNN KICDIAINWA GGLHHAKKFE ASGFCYVNDI VIGILELLKY HPRVLYIDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI NQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLDQIRQ TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP EENYSRPEAP NEFYDGDHDN DKESDVEI
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product HDAC3 蛋白
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Histone Deacetylase 3 (HDAC3) (AA 1-428) protein (GST tag)
HDAC3 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Histone Deacetylase 3 (HDAC3) (AA 319-428) protein (GST tag)HDAC3 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Histone Deacetylase 3 (HDAC3) (AA 1-428) protein (Strep Tag)Crystallography grade HDAC3 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Histone Deacetylase 3 (HDAC3) (AA 1-424) protein (His tag)Crystallography grade HDAC3 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Histone Deacetylase 3 (HDAC3) protein (Myc-DYKDDDDK Tag)HDAC3 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- HDAC3 (Histone Deacetylase 3 (HDAC3))
- 别名
- HDAC3 (HDAC3 产品)
- 别名
- CG2128 Protein, DHDAC3 Protein, DmHDAC3 Protein, Dmel\\CG2128 Protein, Dromel_CG2128_FBtr0078767_hdac3_mORF Protein, HDAC Protein, HDAC3 Protein, Hdac 3 Protein, dHDAC3 Protein, dmHDA402 Protein, hdac3 Protein, HDm Protein, hd3 Protein, RPD3 Protein, XRpd3 Protein, rpd3-2 Protein, HD3 Protein, RPD3-2 Protein, AW537363 Protein, zgc:55927 Protein, Histone deacetylase 3 Protein, histone deacetylase 3 Protein, histone deacetylase 3 S homeolog Protein, HDAC3 Protein, hdac3 Protein, CNL05260 Protein, Hdac3 Protein, hdac3.S Protein
- 背景
- Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elents, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1, increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation . Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI3K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress .
- 分子量
- 64.8 kDa
- UniProt
- O15379
- 途径
- Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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