ACVA Protein (AA 21-426) (His tag)
-
- 抗原 See all ACVA 蛋白
- ACVA (Activin A (ACVA))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 21-426
-
宿主
- 人
-
资源
- HEK-293 Cells
- 标记
- This ACVA protein is labelled with His tag.
- 应用范围
- Functional Studies (Func)
- 序列
- AA 21-426
- 产品特性
- This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 13 kDa (mature) & 32 kDa (pro). As a result of glycosylation and Interchain disulfide bond, the protein migrates as 15 kDa (mature) and 43-48 kDa (pro) under reducing (R) condition, and 27 kDa (mature), 43-48 kDa (pro) and 60 kDa (pro & mature) under non-reducing (NR) condition (SDS-PAGE).
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product ACVA 蛋白
-
Activin A (ACVA) (AA 311-426) (Active) protein
ACVA 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Activin A (ACVA) (AA 311-426) proteinACVA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Activin A (ACVA) (AA 309-424) protein (His tag)ACVA 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Activin A (ACVA) (AA 309-424) protein (His tag)ACVA 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
-
- 抗原
- ACVA (Activin A (ACVA))
- 别名
- Activin A (ACVA 产品)
- 别名
- inhibin beta A subunit Protein, Inhba Protein
- 背景
- Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion. Activins are nonglycosylated homodimers or heterodimers of various β subunits (βA, βB, βC, and βE in mammals), while Inhibins are heterodimers of a unique α subunit and one of the β subunits. Activin A is a widely expressed homodimer of two βA chains. The βA subunit can also heterodimerize with a βB or βC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human βA chain shares 100 % amino acid sequence identity with bovine, feline, mouse, porcine, and rat βA. Activin is produced in the gonads, pituitary gland, placenta, and other organs. The bioactivity of Activin A is regulated by a variety of mechanisms. In the ovarian follicle, activin increases FSH binding and FSH-induced aromatization, Activin is strongly expressed in wounded skin, and overexpression of activin in epidermis of transgenic mice improves wound healing and enhances scar formation, Activin also regulates the morphogenesis of branching organs such as the prostate, lung, and especially kidney. Activin A increased the expression level of type-I collagen suggesting that activin A acts as a potent activator of fibroblasts, Lack of activin during development results in neural developmental defects.
- 分子量
- 13.0 kDa (mature) and 32.0 kDa (pro)
- 途径
- Hormone Transport, Peptide Hormone Metabolism
-
