ITGAV/ITGB5 Protein (AA 31-992) (His tag)
ITGAV/ITGB5
宿主: 人
宿主: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
Func
Active
2 images
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- 抗原 See all ITGAV/ITGB5 products
- ITGAV/ITGB5 (Integrin alpha V / beta 5 (ITGAV/ITGB5))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 31-992
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This ITGAV/ITGB5 protein is labelled with His tag.
- 应用范围
- Functional Studies (Func)
- 序列
- AA 31-992
- 产品特性
- Human ITGAV & ITGB5 Heterodimer Protein, produced by co-expression of ITGAV and ITGB5, has a calculated MW of 113 kDa (ITGAV) and 81.9 kDa (ITGB5). Subunit ITGAV is fused with polyhistidine tag at the C-terminus and followed by a acidic tail and subunit ITGB5 contains no tag but a basic tail at the C-terminus. The reducing (R) protein migrates as 145 kDa (ITGAV) and 100-116 kDa (ITGB5) respectively due to glycosylation.
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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Integrin alpha V / beta 5 (ITGAV/ITGB5) (AA 31-992) protein (His-Avi Tag,Biotin)
ITGAV/ITGB5 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Integrin alpha V / beta 5 (ITGAV/ITGB5) (AA 31-992) protein (His tag,AVI tag,Biotin)ITGAV/ITGB5 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- 50 mM Tris, 150 mM NaCl, pH 7.5
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
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- 抗原
- ITGAV/ITGB5 (Integrin alpha V / beta 5 (ITGAV/ITGB5))
- 别名
- Integrin alpha V beta 5 (ITGAV/ITGB5 产品)
- 背景
- Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.
- 分子量
- 112.9 kDa (ITGAV) & 81.9 kDa (ITGB5)
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