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LIF Protein (AA 24-203) (His tag)

LIF 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
产品编号 ABIN2870754
发货至: 中国
  • 抗原 See all LIF 蛋白
    LIF (Leukemia Inhibitory Factor (LIF))
    蛋白类型
    Recombinant
    产品特性
    AA 24-203
    宿主
    • 19
    • 12
    • 4
    • 3
    • 2
    • 2
    • 1
    小鼠
    资源
    • 20
    • 14
    • 2
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    标记
    This LIF protein is labelled with His tag.
    序列
    AA 24-203
    产品特性
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.7 kDa. The protein migrates as 33-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    纯度
    >90 % as determined by SDS-PAGE.
    内毒素水平
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product LIF 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    PBS, pH 7.4
    注意事项
    Please avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
  • 抗原
    LIF (Leukemia Inhibitory Factor (LIF))
    别名
    LIF (LIF 产品)
    别名
    CDF Protein, DIA Protein, HILDA Protein, MLPLI Protein, LIF, interleukin 6 family cytokine Protein, leukemia inhibitory factor Protein, LIF Protein, Lif Protein
    背景
    Leukemia inhibitory factor, or LIF, an interleukin 6 class cytokine, is a protein in cells that affects cell growth and development.Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Removal of LIF pushes stem cells toward differentiation, but they retain their proliferative potential or pluripotency. Therefore LIF is used in mouse embryonic stem cell culture. It is necessary to maintain the stem cells in an undifferentiated state, however genetic manipulation of embryonic stem cells allows for LIF independent growth, notably overexpression of the gene Nanog. LIF is not required for culture of human embryonic stem cells.
    分子量
    20.8 kDa
    NCBI登录号
    NP_032527
    UniProt
    P09056
    途径
    JAK/STAT Signaling, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Stem Cell Maintenance, Growth Factor Binding
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