Parkin 蛋白
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- 抗原 See all Parkin (PARK2) 蛋白
- Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 应用范围
- Western Blotting (WB), Positive Control (PC)
- 原理
- Purified Protein in ready-to-use SDS sample buffer.
- 纯化方法
- Purified Protein
- Top Product
- Discover our top product PARK2 蛋白
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Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 1-165) protein (His-IF2DI Tag)
PARK2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 1-387) protein (GST tag)PARK2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 288-387) protein (GST tag)PARK2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 1-465) protein (Strep Tag)Crystallography grade PARK2 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 1-464) protein (Strep Tag)Crystallography grade PARK2 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 1-465) protein (His tag)PARK2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 80 % by SDS - PAGE SDS
Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 1-465), (full length) protein (His-SUMO Tag)PARK2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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- 应用备注
- The sample is in ready-to-use buffer for application in SDS-PAGE and Western blotting.
- 说明
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Synonyms: PARK2, E3 ubiquitin-protein ligase parkin antibody, PRKN
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- For 5 applications, volume varies from 100-200 μL in reduced SDS-PAGE sample buffer.
- 储存条件
- -20 °C
- 储存方法
- -20 °C for long term storage
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- 抗原
- Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))
- 别名
- Parkin (PARK2 产品)
- 别名
- CG10523 Protein, Dmel\\CG10523 Protein, Dpark Protein, SD01679 Protein, dpk Protein, AR-JP Protein, LPRS2 Protein, PDJ Protein, PRKN Protein, Park Protein, Prkn Protein, si:ch211-123f21.1 Protein, zgc:112390 Protein, pdr-1 Protein, PARK2 Protein, parkin Protein, parkin RBR E3 ubiquitin protein ligase Protein, Parkinson disease (autosomal recessive, juvenile) 2, parkin Protein, park Protein, PRKN Protein, Prkn Protein, prkn Protein, CpipJ_CPIJ014867 Protein, Park2 Protein
- 背景
- Parkin is a zinc-finger protein with an amino-terminal ubiquitin domain and a carboxy-terminal RING-box. The encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Phosphorylation of Parkin at Ser101 has a regulatory role on its E3 ubiquitin ligase activity. Mutations in this gene cause Parkinson disease and autosomal recessive juvenile Parkinson (AR-JP) disease which is characterized by the progressive loss of dopaminergic neurons and the presence of Lewy bodies in the substania nigra. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Parkin is an ubiquitin-protein ligase expresses in many tissues such as brain, testis, skeletal muscle and heart. In humans, Parkin is highly expressed in the basal ganglia, midbrain, cerebellum and cerebral cortex. Parkin expression is also high in the brainstem of mice, with the majority of immuno positive cells being neurons. It is a RING-type E3 ubiquitin-protein ligase that facilitates the ubiquitination of misfolded proteins by participating in the removal and/or detoxification of abnormally folded or damaged protein. It also plays a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin is an E3 ubiquitin ligase used to reduce intra neuronal amyloid-β (Aβ) levels and enhance autophagic clearance of Aβ-induced defects in AD. Parkin-mediated clearance of ubiquitinated Aβ act in parallel with autophagy to clear molecular debris and defective mitochondria and restore neurotransmitter balance.The human Parkin gene maps to chromosome 6q25.2-q27 and encodes a 465 amino acid protein.
- 分子量
- 56 kDa
- UniProt
- O60260
- 途径
- Autophagy, Ubiquitin Proteasome Pathway
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