EDAR Protein (AA 27-183, Extracellular Domain) (Fc Tag)
EDAR
宿主: 人, 小鼠
宿主: CHO Cells
Recombinant
>95 % (SDS-PAGE)
SDS
Active
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- 抗原 See all EDAR 蛋白
- EDAR (Ectodysplasin A Receptor (EDAR))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- Extracellular Domain, AA 27-183
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宿主
- 人, 小鼠
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资源
- CHO Cells
- 标记
- This EDAR protein is labelled with Fc Tag.
- 应用范围
- SDS-PAGE (SDS)
- 特异性
- Binds to human and mouse EDA-A1.
- 交叉反应
- 人, 小鼠
- 产品特性
- The extracellular domain of human EDAR (aa 27-183) is fused at the C-terminus to the Fc portion of human IgG1.
- 纯度
- >95 % (SDS-PAGE)
- 内毒素水平
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product EDAR 蛋白
-
Ectodysplasin A Receptor (EDAR) (AA 27-183) protein (His-DYKDDDDK-Strep II Tag)
EDAR 宿主: 人 宿主: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Ectodysplasin A Receptor (EDAR) (AA 64-178) protein (GST tag)EDAR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Inhibits EDA-A1 activity.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute with 50 μL sterile water.
- 浓度
- Lot specific
- 缓冲液
- Lyophilized. Contains PBS.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - 有效期
- 6 months
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- 抗原
- EDAR (Ectodysplasin A Receptor (EDAR))
- 别名
- EDAR (EDAR 产品)
- 别名
- rs3 Protein, edar Protein, EDAR Protein, MGC88893 Protein, DL Protein, ECTD10A Protein, ECTD10B Protein, ED1R Protein, ED3 Protein, ED5 Protein, EDA-A1R Protein, EDA1R Protein, EDA3 Protein, HRM1 Protein, dl Protein, RGD1561714 Protein, ectodysplasin A receptor Protein, ectodysplasin-A receptor Protein, edar Protein, EDAR Protein, Edar Protein
- 背景
- The TNF family ligand ectodysplasin A (EDA) and its receptor EDAR are required for proper development of skin appendages such as hair, teeth and eccrine sweat glands. Loss of function mutations in the Eda gene cause X-linked hypohidrotic ectodermal dysplasia (XLHED), a condition that can be ameliorated in mice and dogs by timely administration of recombinant EDA. The Eda gene on the X chromosome is transcribed as multiple splice variants, only two of which code for the receptor-binding C-terminal TNF homology domain. These two variants code for 391- and 389-amino acid-long proteins called EDA1 and EDA2. EDA1 binds EDAR, whereas EDA2 binds to another receptor, XEDAR. The biology of EDA2 and XEDAR is distinct from that of EDA1. Indeed, XEDAR-deficient mice have no obvious ectodermal dysplasia phenotype, whereas mice deficient in EDA, EDAR, or the signaling adaptor protein EDARADD all display virtually indistinguishable ectodermal dysplasia phenotypes, indicating the predominance of the EDA1-EDAR axis in the development of skin-derived appendages.
- 分子量
- ~50kDa (SDS-PAGE)
- UniProt
- Q9UNE0
- 途径
- Tube Formation, Ubiquitin Proteasome Pathway
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