p130 Protein (Myc-DYKDDDDK Tag)
-
- 抗原 See all p130 (RBL2) 蛋白
- p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
- 蛋白类型
- Recombinant
-
宿主
- 人
-
资源
- HEK-293 Cells
- 标记
- This p130 protein is labelled with Myc-DYKDDDDK Tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
-
- Recombinant human RBL2 / p130 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product RBL2 蛋白
-
Retinoblastoma-Like 2 (p130) (RBL2) (AA 416-515) protein (GST tag)
RBL2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Retinoblastoma-Like 2 (p130) (RBL2) (AA 1-1139) protein (Strep Tag)Crystallography grade RBL2 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Retinoblastoma-Like 2 (p130) (RBL2) (AA 1-1135) protein (Strep Tag)Crystallography grade RBL2 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
-
- 应用备注
-
Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
-
The tag is located at the C-terminal.
- 限制
- 仅限研究用
-
- 浓度
- 50 μg/mL
- 缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
-
- 抗原
- p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
- 别名
- Rbl2,p130 (RBL2 产品)
- 别名
- RBL2 Protein, RBR2 Protein, RRB2a Protein, PRB2 Protein, RBR-2 Protein, Rb2 Protein, p130 Protein, P130 Protein, retinoblastoma-like 2 (p130) Protein, RB transcriptional corepressor like 2 Protein, related to retinoblastoma 2 Protein, RBL2 Protein, LOC541652 Protein, Rbl2 Protein
- 背景
- Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. [UniProtKB/Swiss-Prot Function]
- 分子量
- 128.2 kDa
- NCBI登录号
- NP_005602
- 途径
- Cell Division Cycle, Mitotic G1-G1/S Phases
-
