RAN Protein (Myc-DYKDDDDK Tag)
-
- 抗原 See all RAN 蛋白
- RAN (RAN, Member RAS Oncogene Family (RAN))
- 蛋白类型
- Recombinant
-
宿主
- 人
-
资源
- HEK-293 Cells
- 标记
- This RAN protein is labelled with Myc-DYKDDDDK Tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
-
- Recombinant human RAN protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product RAN 蛋白
-
RAN, Member RAS Oncogene Family (RAN) (AA 1-216) protein (His tag)
RAN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % by SDS - PAGE SDS
RAN, Member RAS Oncogene Family (RAN) (AA 1-216) protein (GST tag)RAN 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
RAN, Member RAS Oncogene Family (RAN) (AA 2-216) protein (His tag)Crystallography grade RAN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB, Crys
RAN, Member RAS Oncogene Family (RAN) (AA 2-216) protein (His tag)Crystallography grade RAN 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB, Crys
RAN, Member RAS Oncogene Family (RAN) (AA 2-219) protein (His-SUMO Tag)RAN 宿主: Saccharomyces cerevisiae 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
-
- 应用备注
-
Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
-
The tag is located at the C-terminal.
- 限制
- 仅限研究用
-
- 浓度
- 50 μg/mL
- 缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
-
- 抗原
- RAN (RAN, Member RAS Oncogene Family (RAN))
- 别名
- Ran (RAN 产品)
- 别名
- ARA24 Protein, Gsp1 Protein, TC4 Protein, ran Protein, ara24 Protein, gsp1 Protein, ran-1 Protein, tc4 Protein, RAN Protein, RANP1 Protein, AAF30287 Protein, CG1404 Protein, Dmel\CG1404 Protein, Ran Protein, dran Protein, l(1)G0075 Protein, ran10A Protein, fc16b04 Protein, wu:fc16b04 Protein, RAN, member RAS oncogene family Protein, RAN, member RAS oncogene family S homeolog Protein, CG1404 gene product from transcript CG1404-RC Protein, RAN Protein, Ran Protein, ran.S Protein, ran Protein
- 背景
- RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy&aposs disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy&aposs disease.
- 分子量
- 24.2 kDa
- NCBI登录号
- NP_006316
- 途径
- Regulatory RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus
-
