PREX2 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- 抗原 See all PREX2 (DEPDC2) 蛋白
- PREX2 (DEPDC2) (DEP Domain Containing 2 (DEPDC2))
- 蛋白类型
- Recombinant
- 产品特性
- Transcript Variant 1
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This PREX2 protein is labelled with Myc-DYKDDDDK Tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
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- Recombinant human PREX2 / DEPDC2 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product DEPDC2 蛋白
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DEP Domain Containing 2 (DEPDC2) (AA 1-1606) protein (Strep Tag)
Crystallography grade DEPDC2 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
DEP Domain Containing 2 (DEPDC2) (AA 1-1598) protein (Strep Tag)Crystallography grade DEPDC2 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
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- 应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
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The tag is located at the C-terminal.
- 限制
- 仅限研究用
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- 浓度
- 50 μg/mL
- 缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- 抗原
- PREX2 (DEPDC2) (DEP Domain Containing 2 (DEPDC2))
- 别名
- Prex2,depdc2 (DEPDC2 产品)
- 别名
- 6230420N16Rik Protein, DEP.2 Protein, DEPDC2 Protein, P-REX2 Protein, AI316880 Protein, AI553603 Protein, C030045D06Rik Protein, D430013K02 Protein, Depdc2 Protein, P-Rex2 Protein, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 Protein, phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 Protein, PREX2 Protein, Prex2 Protein
- 背景
- The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers.
- 分子量
- 182.4 kDa
- NCBI登录号
- NP_079146
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