PHLPP1 Protein (Myc-DYKDDDDK Tag)
PHLPP1
宿主: 人
宿主: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
1 image
(2 references)-
- 抗原 See all PHLPP1 products
- PHLPP1 (PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
- 蛋白类型
- Recombinant
- 宿主
- 人
- 资源
- HEK-293 Cells
- 标记
- This PHLPP1 protein is labelled with Myc-DYKDDDDK Tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
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- Recombinant human PHLPP1 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
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- 应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
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The tag is located at the C-terminal.
- 限制
- 仅限研究用
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- 浓度
- 50 μg/mL
- 缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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: "Role of PHLPP1 in inflammation response: Its loss contributes to gliomas development and progression." in: International immunopharmacology, Vol. 34, pp. 229-34, (2016) (PubMed).
: "An ATP-site on-off switch that restricts phosphatase accessibility of Akt." in: Science signaling, Vol. 5, Issue 223, pp. ra37, (2012) (PubMed).
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: "Role of PHLPP1 in inflammation response: Its loss contributes to gliomas development and progression." in: International immunopharmacology, Vol. 34, pp. 229-34, (2016) (PubMed).
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- 抗原
- PHLPP1 (PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
- 别名
- Phlpp1 (PHLPP1 产品)
- 别名
- PHLPP Protein, PLEKHE1 Protein, SCOP Protein, AI836256 Protein, Phlpp Protein, Plekhe1 Protein, mKIAA0606 Protein, Scop Protein, PH domain and leucine rich repeat protein phosphatase 1 Protein, PHLPP1 Protein, phlpp1 Protein, Phlpp1 Protein
- 背景
- This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
- 分子量
- 184.5 kDa
- NCBI登录号
- NP_919431
- 途径
- PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
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