KPNA3 Protein (Myc-DYKDDDDK Tag)
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- 抗原 See all KPNA3 蛋白
- KPNA3 (Karyopherin alpha 3 (Importin alpha 4) (KPNA3))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This KPNA3 protein is labelled with Myc-DYKDDDDK Tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
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- Recombinant human KPNA3 / Importin alpha-3 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product KPNA3 蛋白
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Karyopherin alpha 3 (Importin alpha 4) (KPNA3) (AA 422-521) protein (GST tag)
KPNA3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Karyopherin alpha 3 (Importin alpha 4) (KPNA3) (AA 2-521) protein (His tag)Crystallography grade KPNA3 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Karyopherin alpha 3 (Importin alpha 4) (KPNA3) (AA 2-521) protein (His tag)Crystallography grade KPNA3 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
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The tag is located at the C-terminal.
- 限制
- 仅限研究用
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- 浓度
- 50 μg/mL
- 缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- 抗原
- KPNA3 (Karyopherin alpha 3 (Importin alpha 4) (KPNA3))
- 别名
- Kpna3,importin alpha-3 (KPNA3 产品)
- 别名
- IPOA4 Protein, si:dz79f24.2 Protein, importin Protein, SRP1 Protein, SRP1gamma Protein, SRP4 Protein, hSRP1 Protein, ipoa4 Protein, srp1 Protein, srp1gamma Protein, srp4 Protein, karyopherin (importin) alpha 3 Protein, karyopherin alpha 3 (importin alpha 4) Protein, karyopherin subunit alpha 3 Protein, karyopherin alpha 3 (importin alpha 4) L homeolog Protein, Kpna3 Protein, kpna3 Protein, KPNA3 Protein, kpna3.L Protein
- 背景
- Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9. [UniProtKB/Swiss-Prot Function]
- 分子量
- 57.6 kDa
- NCBI登录号
- NP_002258
- 途径
- Protein targeting to Nucleus
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