HLA-DRB4 Protein (Myc-DYKDDDDK Tag)
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- 抗原 See all HLA-DRB4 蛋白
- HLA-DRB4 (Major Histocompatibility Complex, Class II, DR beta 4 (HLA-DRB4))
- 蛋白类型
- Recombinant
- 宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This HLA-DRB4 protein is labelled with Myc-DYKDDDDK Tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
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- Recombinant human HLA Class II DR beta 4 / HLA-DRB4 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product HLA-DRB4 蛋白
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Major Histocompatibility Complex, Class II, DR beta 4 (HLA-DRB4) (AA 30-266) protein (GST tag)
HLA-DRB4 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Major Histocompatibility Complex, Class II, DR beta 4 (HLA-DRB4) (AA 30-227) protein (His tag)Crystallography grade HLA-DRB4 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
Major Histocompatibility Complex, Class II, DR beta 4 (HLA-DRB4) (AA 30-266) protein (rho-1D4 tag)Crystallography grade HLA-DRB4 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
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- 应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
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The tag is located at the C-terminal.
- 限制
- 仅限研究用
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- 浓度
- 50 μg/mL
- 缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- 抗原
- HLA-DRB4 (Major Histocompatibility Complex, Class II, DR beta 4 (HLA-DRB4))
- 别名
- Hla Class II Dr beta 4,hla-Drb4 (HLA-DRB4 产品)
- 别名
- DR-4 Protein, DR4 Protein, DRB4 Protein, HLA-DR4B Protein, major histocompatibility complex, class II, DR beta 4 Protein, HLA-DRB4 Protein
- 背景
- HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
- 分子量
- 27 kDa
- NCBI登录号
- NP_068818
- 途径
- TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response
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