HGS Protein (Myc-DYKDDDDK Tag)
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- 抗原 See all HGS 蛋白
- HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This HGS protein is labelled with Myc-DYKDDDDK Tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
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- Recombinant human HGS / HRS protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product HGS 蛋白
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Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 1-777) protein (GST tag)
HGS 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 513-612) protein (GST tag)HGS 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 1-777) protein (Strep Tag)Crystallography grade HGS 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 1-775) protein (Strep Tag)Crystallography grade HGS 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
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- 应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
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The tag is located at the C-terminal.
- 限制
- 仅限研究用
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- 浓度
- 50 μg/mL
- 缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- 抗原
- HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))
- 别名
- Hgs,hrs (HGS 产品)
- 别名
- HRS Protein, Hrs Protein, fi34f05 Protein, zgc:63492 Protein, wu:fi34f05 Protein, Hgr Protein, ZFYVE8 Protein, CG2903 Protein, Dmel\\CG2903 Protein, HRS-2 Protein, Vps27 Protein, hrs Protein, l(2)23AB5 Protein, l(2)23Ad Protein, l(2)23Ad(Hrs) Protein, vps27 Protein, hgs Protein, hepatocyte growth factor-regulated tyrosine kinase substrate Protein, HGF-regulated tyrosine kinase substrate Protein, Hepatocyte growth factor regulated tyrosine kinase substrate Protein, hepatocyte growth factor-regulated tyrosine kinase substrate L homeolog Protein, HGS Protein, Hgs Protein, hgs Protein, Hrs Protein, hgs.L Protein
- 背景
- Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. [UniProtKB/Swiss-Prot Function]
- 分子量
- 86 kDa
- NCBI登录号
- NP_004703
- 途径
- EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Synaptic Vesicle Exocytosis, EGFR Downregulation
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