CBL Protein (Myc-DYKDDDDK Tag)
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- 抗原 See all CBL 蛋白
- CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This CBL protein is labelled with Myc-DYKDDDDK Tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
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- Recombinant human CBL / RNF55 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product CBL 蛋白
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Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (AA 1-906) protein (GST tag)
CBL 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (AA 736-835) protein (GST tag)CBL 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (AA 1-906) protein (Strep Tag)Crystallography grade CBL 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (AA 1-913) protein (Strep Tag)Crystallography grade CBL 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
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- 应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
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The tag is located at the C-terminal.
- 限制
- 仅限研究用
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- 浓度
- 50 μg/mL
- 缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- 抗原
- CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
- 别名
- Cbl,rnf55 (CBL 产品)
- 别名
- 4732447J05Rik Protein, Cbl-2 Protein, c-Cbl Protein, cbl Protein, C-CBL Protein, CBL2 Protein, FRA11B Protein, NSLL Protein, RNF55 Protein, c-cbl-like Protein, RGD1561386 Protein, Casitas B-lineage lymphoma Protein, Cbl proto-oncogene Protein, Cbl Protein, CBL Protein
- 背景
- This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5&apos UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
- 分子量
- 99.5 kDa
- NCBI登录号
- NP_005179
- 途径
- TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals
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