WHSC1L1 Protein (AA 1021-1320) (GST tag)
WHSC1L1
宿主: 人
宿主: 大肠杆菌（E. Coli）
Recombinant
EAA, ScA
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- 抗原 See all WHSC1L1 蛋白
- WHSC1L1 (Wolf-Hirschhorn Syndrome Candidate 1-Like 1 (WHSC1L1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1021-1320
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This WHSC1L1 protein is labelled with GST tag.
- 应用范围
- Enzyme Activity Assay (EAA), Screening Assay (ScA)
- 产品特性
- Recombinant WHSC1L1 / NSD3 - SET peptide that includes amino acids 1021-1320 that contains the SET domain sequence of the human WHSC1L1 (NSD3) protein (accession number NP_075447.1) was expressed in E. coli cells and contains an N-terminal GST tag with an observed molecular weight of 60 kDa.
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- Discover our top product WHSC1L1 蛋白
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Wolf-Hirschhorn Syndrome Candidate 1-Like 1 (WHSC1L1) (AA 1021-1322) protein (His tag)
WHSC1L1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Wolf-Hirschhorn Syndrome Candidate 1-Like 1 (WHSC1L1) (AA 1-645) protein (GST tag)WHSC1L1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
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- 应用备注
- Recombinant WHSC1L1 / NSD3 - SET protein is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. Specific Activity: Histone methyltransferase with histone H3 lysine 4 and H3 lysine 27 methyltransferase activity. HMT Assay Conditions: 50 mM TrisCl, pH 8.6, 0.02 % Triton X-100, 2 mM MgCl2, 1 mM TCEP, 100 μM SAM, 30 ng/μl Recombinant Nucleosomes, 400 nM WHSC1L1 / NSD3 - SET at 2 hours at room temperature. AlphaLISA was used for detection.
- 限制
- 仅限研究用
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- 注意事项
- Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- 储存条件
- -80 °C
- 储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
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- 抗原
- WHSC1L1 (Wolf-Hirschhorn Syndrome Candidate 1-Like 1 (WHSC1L1))
- 别名
- WHSC1L1 / NSD3 (WHSC1L1 产品)
- 别名
- WHSC1L1 Protein, NSD3 Protein, pp14328 Protein, 6720429E03 Protein, A530023P05 Protein, AI528490 Protein, WHISTLE Protein, nuclear receptor binding SET domain protein 3 Protein, Wolf-Hirschhorn syndrome candidate 1-like 1 Protein, Nsd3 Protein, WHSC1L1 Protein, NSD3 Protein, nsd3 Protein, LOC100228404 Protein
- 背景
- WHSC1L1 (Wolf-Hirschhorn Syndrome Candidate 1-Like 1), also known as NSD3, is a histone methyltransferase that preferentially methylates lysine 4 and lysine 27 of histone H3. H3 lysine 4 methylation represents a specific tag for epigenetic transcriptional activation, while H3 lysine 27 methylation is a mark for transcriptional repression. The WHSC1L1 gene is amplified in several cancers, including lung cancer and head and neck cancer, and may play a role in carcinogenesis. WHSC1L1 / NSD3 - SET includes the SET domain of WHSC1L1. The SET domain is a 130 to 140 amino acid, evolutionary conserved motif that was initially characterized in the Drosophila proteins Su(var)3-9, EZH2 and TrxG and plays a crucial role in substrate recognition and enzymatic activity.
- 分子量
- 60 kDa
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