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- 抗原 See all SETMAR 蛋白
- SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus
- 标记
- This SETMAR protein is labelled with DYKDDDDK Tag.
- 应用范围
- Enzyme Activity Assay (EAA), Screening Assay (ScA)
- 产品特性
- Recombinant SETMAR (accession number NP_006506.3) was expressed in Sf9 cells and contains an N-terminal FLAG tag with an observed molecular weight of 79 kDa.
- Top Product
- Discover our top product SETMAR 蛋白
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SET Domain and Mariner Transposase Fusion Gene (SETMAR) (AA 1-352) protein (GST tag)
SETMAR 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
SET Domain and Mariner Transposase Fusion Gene (SETMAR) (AA 1-684) protein (Strep Tag)Crystallography grade SETMAR 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
SET Domain and Mariner Transposase Fusion Gene (SETMAR) (AA 1-309) protein (Strep Tag)Crystallography grade SETMAR 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
SET Domain and Mariner Transposase Fusion Gene (SETMAR) (AA 1-118), (full length) protein (His tag)SETMAR 宿主: 人 宿主: 酵母菌 Recombinant > 90 % SDS
SET Domain and Mariner Transposase Fusion Gene (SETMAR) protein (Myc-DYKDDDDK Tag)SETMAR 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Recombinant SETMAR is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
- 限制
- 仅限研究用
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- 注意事项
- Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- 储存条件
- -80 °C
- 储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
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- 抗原
- SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))
- 别名
- SETMAR (SETMAR 产品)
- 别名
- HsMar1 Protein, METNASE Protein, Mar1 Protein, 5830404F24Rik Protein, Etet2 Protein, SETMAR Protein, zgc:172212 Protein, SET domain and mariner transposase fusion gene Protein, SET domain without mariner transposase fusion Protein, histone-lysine N-methyltransferase SETMAR Protein, SETMAR Protein, Setmar Protein, LOC470738 Protein, setmar Protein, LOC703880 Protein, LOC100447656 Protein, LOC100586616 Protein
- 背景
- SETMAR (SET Domain and mariner transposase fusion gene) is a ubiquitously expressed nuclear fusion protein that contains an N-terminal SET domain with histone methyltransferase activity and a C-terminal mariner (MAR) transposase domain that recognizes and binds DNA. The gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. SETMAR binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The mariner transposase domain recognizes and binds the 19-mer core of the 5'-TIR (terminal inverted repeats) of the Hsmar1 element. The SET domain specifically methylates lysines 4 and 36 of histone H3 which are epigenetic marks associated with transcriptional activation. SETMAR demonstrates in vivo end joining activity and may mediate genomic integration of foreign DNA.
- 分子量
- 79 kDa
- 途径
- Positive Regulation of Response to DNA Damage Stimulus
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