IGF2 Protein (AA 25-91)
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- 抗原 See all IGF2 蛋白
- IGF2 (Insulin-Like Growth Factor 2 (IGF2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 25-91
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 应用范围
- Immunoprecipitation (IP), Flow Cytometry (FACS)
- 纯度
- >98 % , as determined by Coomassie stained SDS-PAGE and HPLC analysis.
- 内毒素水平
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Less than 0.1 ng per μg of protein.
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- Discover our top product IGF2 蛋白
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Insulin-Like Growth Factor 2 (IGF2) (AA 1-113) protein (GST tag)
IGF2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Insulin-Like Growth Factor 2 (IGF2) (AA 25-114) protein (GST tag)IGF2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Insulin-Like Growth Factor 2 (IGF2) (AA 1-180) protein (GST tag)IGF2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Insulin-Like Growth Factor 2 (IGF2) (AA 25-91) (Active) protein (Fc Tag)IGF2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Insulin-Like Growth Factor 2 (IGF2) (AA 30-180), (partial) protein (GST tag)IGF2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 90 % SDS, ELISA
Insulin-Like Growth Factor 2 (IGF2) (AA 25-91) (Active) protein (AVI tag,Fc Tag,Biotin)IGF2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Biological activity: ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5.0 x 105 units/mg as determined by its ability to stimulate the proliferation of mouse FDC-P1 cells.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer, such as 5 % Trehalose, and store working aliquots at -20 °C to -80 °C.
- 缓冲液
- Lyophilized, carrier-free.
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- Unopened vial can be stored at -20°C or -70°C.
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- 抗原
- IGF2 (Insulin-Like Growth Factor 2 (IGF2))
- 别名
- IGF-II (IGF2 产品)
- 别名
- C11orf43 Protein, IGF-II Protein, PP9974 Protein, LOC100136550 Protein, igf2 Protein, igf2b Protein, wu:fc26e03 Protein, zgc:91781 Protein, igf-2 Protein, insigf Protein, pp9974 Protein, AL033362 Protein, Igf-2 Protein, Igf-II Protein, M6pr Protein, Mpr Protein, Peg2 Protein, IGFII Protein, RNIGF2 Protein, IGF-II-B Protein, igf2-a Protein, igf2-b Protein, insulin like growth factor 2 Protein, insulin-like growth factor II Protein, insulin-like growth factor 2a Protein, insulin like growth factor 2 S homeolog Protein, insulin-like growth factor 2 Protein, insulin-like growth factor 2 (somatomedin A) Protein, insulin like growth factor 2 L homeolog Protein, IGF2 Protein, LOC100136550 Protein, igf2a Protein, igf2.S Protein, Igf2 Protein, igf2.L Protein
- 背景
- IGF-II is a member of the IGF family, comprised of three members (IGF-I, IGF-II, and insulin). IGF-I and IGF-II share approximately 50 % similarity with insulin at the amino acid level. IGF-II is synthesized as a 180 amino acid prepro-IGF-II, pro-IGF-II is processed to its mature, active protein form by glucose regulating protein 94 (GRP94), which possesses chaperone activity towards IGF-II. GRP94 and IGF-II play a key role in muscle differentiation. Seven binding proteins have been described (IGFBP-1 to -7). IGFBPs extend the half life and regulate the availability of the IGFI and IGFII. It has been described that IGFBP3 is the main circulating binding protein for IGFs, in serum, approximately 75 % of circulating IGF-I and IGF-II bind to IGFBP3 and the co-carrier acid labile subunit (ALS). IGF-II binds to three receptors, and the binding to IGFIR promotes cell proliferation, survival, differentiation, and migration as well as metabolic function of IGF-II. Embryonic stem cell differentiation into endothelial cells is promoted by the binding of IGF-II to IGFR1. IGF-II binding to IGF-IIR induces internalization and clearing of IGF-II. Osteogenic differentiation and bone formation is enhanced by IGF-II through bone morphogenetic protein-9 (BMP-9). Polymorphisms of IGF-II are associated with obesity, cardiovascular risk factors, and hypertension.
- 分子量
- The 67 amino acid recombinant protein has a predicted molecular mass of approximately 7.5 kDa. The N-terminal amino acid is Ala.
- 途径
- Hormone Activity, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Carbohydrate Metabolic Process, Activated T Cell Proliferation
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