BACE1 Protein (His tag)
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- 抗原 See all BACE1 蛋白
- BACE1 (Beta-secretase 1 (BACE1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This BACE1 protein is labelled with His tag.
- 应用范围
- Western Blotting (WB)
- 产品特性
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Measured by its ability to cleave a fluorogenic peptide substrate, Mca-SEVNLDAEFRK(Dpn)RR-NH2. The specific activity is >3. 5 pmoles/min/μg.
- 纯度
- >95 % as determined by SDS-PAGE.
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- Discover our top product BACE1 蛋白
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Beta-secretase 1 (BACE1) (AA 22-457) protein (Fc Tag)
BACE1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Beta-secretase 1 (BACE1) (AA 22-457) protein (His tag)BACE1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Beta-secretase 1 (BACE1) (AA 22-457) protein (His tag)BACE1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Beta-secretase 1 (BACE1) (AA 46-152) protein (His-IF2DI Tag)BACE1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Beta-secretase 1 (BACE1) (AA 22-501) protein (GST tag)BACE1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Beta-secretase 1 (BACE1) (Active) protein (His tag)BACE1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
Beta-secretase 1 (BACE1) (AA 22-457) proteinBACE1 宿主: 人 宿主: HEK-293 Cells Recombinant >98 % as determined by SDS-PAGE.
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- 应用备注
- This recombinant protein can be used for WB. For research use only.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 储存条件
- -80 °C,-20 °C
- 储存方法
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
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- 抗原
- BACE1 (Beta-secretase 1 (BACE1))
- 别名
- BACE1 (BACE1 产品)
- 别名
- ASP2 Protein, BACE Protein, HSPC104 Protein, C76936 Protein, Bace Protein, MGC145931 Protein, BACE1 Protein, zgc:77409 Protein, beta-secretase 1 Protein, beta-site APP cleaving enzyme 1 Protein, beta-site APP-cleaving enzyme 1 Protein, BACE1 Protein, Bace1 Protein, bace1 Protein
- 背景
- Beta-secretase 1 (BACE1) is also known as beta-site APP cleaving enzyme 1 (beta-site amyloid precursor protein cleaving enzyme 1), memapsin-2 (membrane-associated aspartic protease 2), and aspartyl protease 2 (ASP2), β-Secretase , and is a member of the peptidase A1 protein family, BACE1 is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. BACE1 is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer. This protease is responsible for the proteolytic processing of the amyloid precursor protein (APP). Generation of the 40 or 42 amino acid-long amyloid-β peptides that aggregate in the brain of Alzheimer's patients requires two sequential cleavages of the APP. Extracellular cleavage of APP by BACE creates a soluble extracellular fragment and a cell membrane-bound fragment referred to as C99. The elevation of BACE1 levels can be induced by amyloid plaques surrounding neurons at early stages of pathology before neuron death occurs, and may drive a positive-feedback loop in AD.
- 分子量
- 49.2 kDa
- 基因ID
- 23621
- NCBI登录号
- NP_036236
- UniProt
- P56817
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