The ED50 was determined by the dose - dependent proliferation of murine D10S cells is < 0.005 ng/mL, corresponding to a specific activity of > 2 x 108 units/mg.
内毒素水平
Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
As with any protein, exposing IL-1 alpha recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
储存条件
-20 °C
储存方法
The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted IL-1 alpha is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
有效期
24 months
抗原
IL1A
(Interleukin 1 alpha (IL1A))
别名
IL-1 alpha
背景
IL-1beta is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1beta is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant rat IL-1α is a 17.7 kDa protein containing 155 amino acid residues.