GDNF 蛋白
Our Local Distributor
北京 101111
Quick Overview for GDNF 蛋白 (ABIN2468482)
抗原
See all GDNF 蛋白蛋白类型
生物活性
宿主
资源
纯度
-
-
序列
- MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI
-
产品特性
- The ED50 was determined by the proliferation of rat C6 cells is < 0.2 ng/mL, corresponding to a specific activity of > 5 x 106 units/mg.
-
内毒素水平
- Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
-
-
Glial Cell Line Derived Neurotrophic Factor (GDNF) protein (Biotin)
GDNF 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant WB, FACS, FM, IF, LCI
Glial Cell Line Derived Neurotrophic Factor (GDNF) (AA 78-211) protein (His-IF2DI Tag)GDNF 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Glial Cell Line Derived Neurotrophic Factor (GDNF) (AA 78-211) protein (His-IF2DI Tag)GDNF 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Glial Cell Line Derived Neurotrophic Factor (GDNF) (AA 1-211) protein (GST tag)GDNF 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Glial Cell Line Derived Neurotrophic Factor (GDNF) (AA 78-211) protein (Fc Tag)GDNF 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Glial Cell Line Derived Neurotrophic Factor (GDNF) proteinGDNF 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 98,00% SDS
Glial Cell Line Derived Neurotrophic Factor (GDNF) proteinGDNF 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 98,00% SDS
-
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
注意事项
- As with any protein, exposing GDNF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
-
储存条件
- -20 °C
-
储存方法
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted GDNF is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
-
有效期
- 24 months
-
-
- GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))
-
别名
- GDNF
-
背景
- GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFR α(α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional murine GDNF ligand is a disulfide-linked homodimer, of two 15.1 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
-
基因ID
- 14573
-
NCBI登录号
- NP_034405
-
OMIM
- 7110601
-
UniProt
- P48540
-
途径
- RTK signaling, Synaptic Membrane, Tube Formation, Autophagy, Smooth Muscle Cell Migration
抗原
-
