CLEC4G
(C-Type Lectin Domain Family 4, Member G (CLEC4G))
蛋白类型
Recombinant
产品特性
AA 55-293
宿主
人
资源
HEK-293 Cells
标记
This CLEC4G protein is labelled with Fc Tag.
序列
AA 55-293
产品特性
This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 52.1 kDa. The protein migrates as 65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Crystallography grade
CLEC4G
宿主: 小鼠
宿主: Insect Cells
Recombinant
>95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
WB, ELISA, SDS, Crys
限制
仅限研究用
状态
Lyophilized
缓冲液
50 mM Tris, 100 mM Glycine, pH 7.5
注意事项
Please avoid repeated freeze-thaw cycles.
储存条件
-20 °C
储存方法
Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -71 °C. Avoid repeated freeze-thaw cycles.
Yu, Huang, Chen, Liu, Wu, Pu, Wang, Kang, Zhou: "Characterization of a novel anti-human lymphocyte activation gene 3 (LAG-3) antibody for cancer immunotherapy." in: mAbs, Vol. 11, Issue 6, pp. 1139-1148, (2019) (PubMed).
抗原
CLEC4G
(C-Type Lectin Domain Family 4, Member G (CLEC4G))
RGD1562320 Protein, DTTR431 Protein, LP2698 Protein, LSECtin Protein, UNQ431 Protein, 4930572L20Rik Protein, C-type lectin domain family 4 member G Protein, C-type lectin domain family 4, member G Protein, C-type lectin domain family 4, member g Protein, CLEC4G Protein, Clec4g Protein
背景
C-type lectin superfamily 4, member G (CLEC4G) is also known as liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), which is a member of subgroup II of the C-type (Ca2+-dependent) lectin superfamily. CLEC4G / LSECtin binds to mannose, GlcNAc, and fucose in a Ca2+-dependent manner. In addition, CLEC4G / LSECtin has the ability to bind to surface glycoproteins of enveloped viruses. In particular, interaction of LSECtin with the surface glycoproteins of severe acute respiratory syndrome (SARS) coronavirus and Ebola virus has been described, and LSECtin-mediated infection of cells by Ebola virus has been demonstrated.