SERPINA1
(serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1))
蛋白类型
Recombinant
产品特性
AA 25-418
宿主
人
资源
HEK-293 Cells
标记
This SERPINA1 protein is labelled with His tag.
序列
AA 25-418
产品特性
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 45.1 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
SERPINA1
宿主: 人
宿主: HEK-293 Cells
Recombinant
> 97 % by SDS-PAGE.
Active
限制
仅限研究用
状态
Lyophilized
缓冲液
PBS, pH 7.4
注意事项
Please avoid repeated freeze-thaw cycles.
储存条件
-20 °C
储存方法
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
抗原
SERPINA1
(serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1))
AACT Protein, ACT Protein, GIG25 Protein, A1AT Protein, PI Protein, alpha-1-PI Protein, A1A Protein, AAT Protein, PI1 Protein, PRO2275 Protein, alpha1AT Protein, Pi Protein, Spi1 Protein, MGC64429 Protein, serpina1d Protein, Aps Protein, SERPINA3-5 Protein, serpin family A member 3 Protein, alpha-1-antiproteinase F precursor Protein, serpin family A member 1 Protein, alpha-1-antitrypsin Protein, calumenin Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 Protein, SH2B adaptor protein 2 Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 L homeolog Protein, SERPINA3 Protein, LOC100008973 Protein, SERPINA1 Protein, LOC100328621 Protein, CALU Protein, Serpina1 Protein, serpina1.S Protein, serpina1 Protein, SPIA5 Protein, Sh2b2 Protein, Calu Protein, serpina1.L Protein
背景
Serpin A1 is also known as Alpha-1-antitrypsin (A1AT), serum trypsin inhibitor, alpha-1 proteinase inhibitor (A1PI), AAT, which belongs to the serpin family. Most serpins inactivate enzymes by binding to them covalently, requiring very high levels to perform their function. Like all serine protease inhibitors, A1AT has a characteristic secondary structure of beta sheets and alpha helices. Serpin A1 / A1AT is inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form of SerpinA1 inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Serpin A1 / A1AT protects tissues from enzymes of inflammatory cells, especially neutrophil elastase. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD).