IL12 Protein (AA 23-219, AA 23-328)
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Quick Overview for IL12 Protein (AA 23-219, AA 23-328) (ABIN2018013)
抗原
See all IL12 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 23-219, AA 23-328
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产品特性
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EC50 < 2 ng/mL, measured by the induction of IFN-gamma from NK cells co-stimulated with IL-18, corresponding to a specific activity of > 1x10^6 units/mg.
P35 subunit: AA 23-219 ,P40 subunit: AA 23-328 -
内毒素水平
- < 0.2 EU/μg, determined by LAL method.
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Interleukin 12 (IL12) (AA 23-328) protein (His-Avi Tag)
IL12 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by SEC-HPLC
Interleukin 12 (IL12) (AA 23-328) protein (His-Avi Tag,Biotin)IL12 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 12 (IL12) (AA 23-328) (Active) protein (His tag,DYKDDDDK Tag)IL12 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 12 (IL12) (AA 23-328) (Active) protein (His tag,AVI tag,DYKDDDDK Tag,Biotin)IL12 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 12 (IL12) proteinIL12 宿主: 小鼠 宿主: 人细胞 Recombinant > 90 % as determined by SDS-PAGE
Interleukin 12 (IL12) protein (His tag)IL12 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Interleukin 12 (IL12) (AA 23-219) protein (Fc-His Tag)IL12 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 12 (IL12) (AA 23-328) (Active) protein (His tag)IL12 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % SDS, AcA Active
Interleukin 12 (IL12) proteinIL12 宿主: 人 宿主: HEK-293 Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
Interleukin 12 (IL12) proteinIL12 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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缓冲液
- Lyophilized after extensive dialysis against PBS.
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储存条件
- -80 °C
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储存方法
- Lyophilized recombinant Human Interleukin 12(IL-12) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rh-IL12 should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
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有效期
- 6 months
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- IL12 (Interleukin 12 (IL12))
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别名
- Interleukin 12(IL-12)
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背景
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Interleukin 12 (IL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine originally identified in the medium of activated human B lymphoblastoid cell lines. The p40 subunit of IL-12 has been shown to have extensive amino acid sequence homology to the extracellular domain of the human IL-6 receptor while the p35 subunit shows distant but significant sequence similarity to IL-6, G-CSF, and chicken MGF. These observations have led to the suggestion that IL-12 might have evolved from a cytokine/soluble receptor complex. Human and mouse IL-12 share 70 % and 60 % amino acid sequence homology in their p40 and p35 subunits, respectively. IL-12 apparently shows species specificity with human IL-12 reportedly showing minimal activity in the mouse system.
Synonyms: NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF -
分子量
- 75 kDa, consisting of a 306 amino acid residue p40 subunit and a 197 amino acid residue p35 subunit.
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UniProt
- P29459, P29460
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途径
- JAK/STAT Signaling, TLR signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
抗原
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